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TAS2R5
Identifiers
Aliases	TAS2R5 , T2R5, taste 2 receptor member 5
External IDs	OMIM: 605062 HomoloGene: 49580 GeneCards: TAS2R5
Gene location (Human)
Chr.	Chromosome 7 (human)
End	141,791,367 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; canal of the cervix; ; tibial nerve; ; skin of abdomen; ; gastric mucosa; ; stromal cell of endometrium; ; left uterine tube; ; right coronary artery; ; minor salivary gland; ; pituitary gland;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity ; signal transducer activity ; taste receptor activity ; bitter taste receptor activity ;
Cellular component	plasma membrane ; membrane ; integral component of membrane ;
Biological process	chemosensory behavior ; detection of chemical stimulus involved in sensory perception of bitter taste ; sensory perception of taste ; signal transduction ; response to stimulus ; G protein-coupled receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	54429
	n/a
	ENSG00000127366
	n/a
	Q9NYW4
	n/a
	NM_018980
	n/a
	NP_061853
	n/a
	Wikidata
View/Edit Human

TAS2R5

Last updated March 04, 2023

Taste receptor type 2 member 5 is a protein that in humans is encoded by the TAS2R5 gene.^[3]

Function

This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception.^[3]

Related Research Articles

TAS2R16 is a human gene that encodes for a receptor that may play a role in the perception of bitterness.

Taste receptor type 2 member 1 (TAS2R1/T2R1) is a protein that in humans is encoded by the TAS2R1 gene. It belongs to the G protein-coupled receptor (GPCR) family and is related to class A-like GPCRs, they contain 7 transmembrane helix bundles and short N-terminus loop. Furthermore, TAS2R1 is member of the 25 known human bitter taste receptors, which enable the perception of bitter taste in the mouth cavity. Increasing evidence indicates a functional role of TAS2Rs in extra-oral tissues.

Taste receptor type 2 member 3 is a protein that in humans is encoded by the TAS2R3 gene.

Taste receptor type 2 member 4 is a protein that in humans is encoded by the TAS2R4 gene.

Taste receptor type 2 member 8 is a protein that in humans is encoded by the TAS2R8 gene.

Taste receptor type 2 member 9 is a protein that in humans is encoded by the TAS2R9 gene.

Taste receptor type 2 member 10 is a protein that in humans is encoded by the TAS2R10 gene.

Taste receptor type 2 member 13 is a protein that in humans is encoded by the TAS2R13 gene.

Taste receptor type 2 member 7 is a protein that in humans is encoded by the TAS2R7 gene.

Taste receptor type 1 member 1 is a protein that in humans is encoded by the TAS1R1 gene.

Taste receptor type 1 member 2 is a protein that in humans is encoded by the TAS1R2 gene.

Taste receptor type 2 member 39 is a protein that in humans is encoded by the TAS2R39 gene.

Taste receptor type 2 member 40 is a protein that in humans is encoded by the TAS2R40 gene.

Taste receptor type 2 member 43 is a protein that in humans is encoded by the TAS2R43 gene.

Taste receptor type 2 member 45 is a protein that in humans is encoded by the TAS2R45 gene.

Taste receptor type 2 member 30 is a protein that in humans is encoded by the TAS2R30 gene.

Taste receptor type 2 member 19 is a protein that in humans is encoded by the TAS2R19 gene. It seems to be involved in the perception of salt and bitter tastes.

Taste receptor type 2 member 20 is a protein that in humans is encoded by the TAS2R20 gene.

Taste receptor type 2 member 50 is a protein that in humans is encoded by the TAS2R50 gene.

Taste receptor type 2 member 60 is a protein that in humans is encoded by the TAS2R60 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000127366 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: TAS2R5 taste receptor, type 2, member 5".

Kinnamon SC (2000). "A plethora of taste receptors". Neuron. 25 (3): 507–10. doi: 10.1016/S0896-6273(00)81054-5 . PMID 10774719.
Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi: 10.1074/jbc.R100054200 . PMID 11696554.
Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982. S2CID 37807140.
Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS (2007). "The receptors and cells for mammalian taste". Nature. 444 (7117): 288–94. doi:10.1038/nature05401. PMID 17108952. S2CID 4431221.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC 16267 . PMID 10737800.
Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi: 10.1016/S0092-8674(00)80705-9 . PMID 10761934. S2CID 14604586.
Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). "T2Rs function as bitter taste receptors". Cell. 100 (6): 703–11. doi: 10.1016/S0092-8674(00)80706-0 . PMID 10761935. S2CID 7293493.
Firestein S (2000). "The good taste of genomics". Nature. 404 (6778): 552–3. doi: 10.1038/35007167 . PMID 10766221. S2CID 35741332.
Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–4. Bibcode:2000Natur.404..601M. doi:10.1038/35007072. PMID 10766242. S2CID 4336913.
Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi: 10.1016/S0092-8674(03)00071-0 . PMID 12581520. S2CID 718601.
Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi: 10.1093/molbev/msi027 . PMID 15496549.
Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719 . PMID 15744053.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000127366 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] 1 2 "Entrez Gene: TAS2R5 taste receptor, type 2, member 5".

[1]

[2]

[3]

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TAS2R5

Contents

Function

See also

Related Research Articles

References

Further reading