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GNRHR2

Last updated
GNRHR2
Identifiers
Aliases GNRHR2 , GnRH-II-R, gonadotropin releasing hormone receptor 2 (pseudogene)
External IDs GeneCards: GNRHR2; OMA:GNRHR2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

114814

n/a

Ensembl

ENSG00000211451

n/a

UniProt

n
a

n/a

RefSeq (mRNA)

NM_057163
NM_206994

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC) Chr 1: 145.92 – 145.93 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Putative gonadotropin-releasing hormone II receptor is a protein that in humans is encoded by the GNRHR2 gene. [3] [4]

Contents

Function

The receptor for gonadotropin-releasing hormone 2 (GnRH2) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane G protein-coupled receptor. However, in humans, the N-terminus of the predicted protein contains a frameshift and premature stop codon. In humans, GnRHR2 transcription occurs but whether the gene produces a functional C-terminal multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribed pseudogene of GnRHR2 is also on chromosome 14. [4]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000211451 – Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ Faurholm B, Millar RP, Katz AA (Nov 2001). "The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci". Genomics. 78 (1–2): 15–8. doi:10.1006/geno.2001.6650. PMID   11707068.
  4. 1 2 "Entrez Gene: GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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