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DPF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3IUF
Identifiers
Aliases	DPF2 , REQ, UBID4, ubi-d4, double PHD fingers 2, CSS7, SMARCG2
External IDs	OMIM: 601671 MGI: 109529 HomoloGene: 21265 GeneCards: DPF2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,354,262 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,963,038 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; Achilles tendon; ; ganglionic eminence; ; canal of the cervix; ; left uterine tube; ; smooth muscle tissue; ; right uterine tube; ; popliteal artery; ; gastric mucosa;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; primitive streak; ; mirror; ; neural tube; ; molar; ; lip; ; saccule; ; thymus; ; medial ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; protein binding ; nucleic acid binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ; transcription corepressor activity ; histone acetyltransferase activity ; histone binding ; H3K9me3 modified histone binding ; lysine-acetylated histone binding ;
Cellular component	nucleus ; nucleoplasm ; intracellular membrane-bounded organelle ; centrosome ; cytoplasm ; cytosol ; histone acetyltransferase complex ; nBAF complex ;
Biological process	regulation of transcription, DNA-templated ; transcription, DNA-templated ; apoptotic signaling pathway ; apoptotic process ; negative regulation of transcription by RNA polymerase II ; chromatin organization ; nervous system development ; histone acetylation ; negative regulation of transcription, DNA-templated ; positive regulation of transcription by RNA polymerase II ; negative regulation of myeloid progenitor cell differentiation ;
	Sources:Amigo / QuickGO
Orthologs
	5977
	19708
	ENSG00000133884
	ENSMUSG00000024826
	Q92785
	Q61103
	NM_006268 ; NM_001330308
	NM_001291078 ; NM_011262
	NP_001317237 ; NP_006259 ; NP_006259.1
	NP_001278007 ; NP_035392
	Wikidata
View/Edit Human	View/Edit Mouse

DPF2

Last updated October 29, 2022

Zinc finger protein ubi-d4 is a protein that in humans is encoded by the DPF2 gene.^[5]^[6]

The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.^[6]

Related Research Articles

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Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.

Zinc finger protein OZF is a protein that in humans is encoded by the ZNF146 gene.

Zinc finger protein 638 is a protein that in humans is encoded by the ZNF638 gene.

Zinc finger protein 655 is a protein that in humans is encoded by the ZNF655 gene.

Zinc finger protein 219 is a protein that in humans is encoded by the ZNF219 gene.

Zinc finger protein 91 homolog is a protein that in humans is encoded by the ZFP91 gene.

Transcription elongation factor A protein-like 1 is a protein that in humans is encoded by the TCEAL1 gene.

Protein Jade-3 is a protein that in humans is encoded by the PHF16 gene.

Zinc finger protein 267 is a protein that in humans is encoded by the ZNF267 gene.

Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.

Zinc finger protein 330 is a protein that in humans is encoded by the ZNF330 gene.

Zinc finger protein 44 is a protein that in humans is encoded by the ZNF44 gene.

Zinc finger protein 19 is a protein that in humans is encoded by the ZNF19 gene.

Zinc finger protein 22 is a protein that in humans is encoded by the ZNF22 gene.

Zinc finger protein 33B is a protein that in humans is encoded by the ZNF33B gene.

Zinc finger protein 41 is a protein that in humans is encoded by the ZNF41 gene.

Zinc finger protein 264 is a protein that in humans is encoded by the ZNF264 gene.

Zinc finger protein 300 is a protein that in humans is encoded by the ZNF300 gene. The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and a likely transcription factor.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000133884 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024826 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ninkina NN, Mertsalov IB, Kulikova DA, Alimova-Kost MV, Simonova OB, Korochkin LI, Kiselev SL, Buchman VL (Feb 2002). "Cerd4, third member of the d4 gene family: expression and organization of genomic locus". Mamm Genome. 12 (11): 862–6. doi:10.1007/s00335-001-3039-1. PMID 11845289. S2CID 2149578.
1 2 "Entrez Gene: DPF2 D4, zinc and double PHD fingers family 2".

External links

DPF2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000133884 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024826 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11845289-5] Ninkina NN, Mertsalov IB, Kulikova DA, Alimova-Kost MV, Simonova OB, Korochkin LI, Kiselev SL, Buchman VL (Feb 2002). "Cerd4, third member of the d4 gene family: expression and organization of genomic locus". Mamm Genome. 12 (11): 862–6. doi:10.1007/s00335-001-3039-1. PMID 11845289. S2CID 2149578.

[entrez-6] 1 2 "Entrez Gene: DPF2 D4, zinc and double PHD fingers family 2".

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DPF2

Contents

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References

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