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ZBTB7B
Identifiers
Aliases	ZBTB7B , THPOK, ZBTB15, ZFP-67, ZFP67, ZNF857B, c-KROX, hcKROX, CKROX, zinc finger and BTB domain containing 7B
External IDs	OMIM: 607646 MGI: 102755 HomoloGene: 7605 GeneCards: ZBTB7B
Gene location (Human)
Chr.	Chromosome 1 (human)
End	155,018,523 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,302,083 bp
RNA expression pattern
	Top expressed in
	monocyte; ; skin of abdomen; ; nipple; ; cardia; ; body of stomach; ; salivary gland; ; minor salivary gland; ; parotid gland; ; rectum; ; body of tongue;
	Top expressed in
	pyloric antrum; ; lip; ; esophagus; ; mirror; ; yolk sac; ; gastric mucosa; ; duodenum; ; Epithelium of stomach; ; jejunum; ; colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding ; protein binding ; metal ion binding ; nucleic acid binding ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; DNA-binding transcription activator activity, RNA polymerase II-specific ; DNA-binding transcription factor activity ; DNA-binding transcription factor activity, RNA polymerase II-specific ; cis-regulatory region sequence-specific DNA binding ; protein homodimerization activity ; histone deacetylase binding ;
Cellular component	nucleus ; nucleoplasm ;
Biological process	multicellular organism development ; ectoderm development ; cell differentiation ; regulation of transcription, DNA-templated ; transcription by RNA polymerase II ; transcription, DNA-templated ; regulation of CD4-positive, alpha-beta T cell differentiation ; regulation of CD8-positive, alpha-beta T cell differentiation ; positive regulation of transcription by RNA polymerase II ; regulation of gene expression ; negative regulation of T-helper 17 cell differentiation ; lactation ; positive regulation of gene expression ; response to insulin ; positive regulation of CD4-positive, alpha-beta T cell differentiation ; negative regulation of CD8-positive, alpha-beta T cell differentiation ; positive regulation of insulin receptor signaling pathway ; positive regulation of brown fat cell differentiation ; adaptive thermogenesis ; positive regulation of SREBP signaling pathway ; negative regulation of transcription by RNA polymerase II ; NK T cell differentiation ; negative regulation of gene expression ; positive regulation of histone deacetylation ; negative regulation of NK T cell proliferation ; positive regulation of cold-induced thermogenesis ;
	Sources:Amigo / QuickGO
Orthologs
	51043
	22724
	ENSG00000160685
	ENSMUSG00000028042
	O15156
	Q64321
NM_001252406 ; NM_001256455 ; NM_001377451 ; NM_001377452 ; NM_001377453 ;
	NM_001377454 ; NM_001377455
	NM_009565 ; NM_001355206 ; NM_001355211 ; NM_001355212
NP_001239335 ; NP_001243384 ; NP_001364380 ; NP_001364381 ; NP_001364382 ;
	NP_001364383 ; NP_001364384
	NP_033591 ; NP_001342135 ; NP_001342140 ; NP_001342141
	Wikidata
View/Edit Human	View/Edit Mouse

ZBTB7B

Last updated October 12, 2022

Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ZBTB7B gene.^[5]^[6]^[7]ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes (e.g. COL1A1; MIM 120150) and has a role in development.[supplied by OMIM]^[7]

Related Research Articles

Collagen alpha-1 (XXVII) chain (COL27A1) is a protein that in humans is encoded by the COL27A1 gene.

Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.

Nucleus accumbens-associated protein 1 is a protein that in humans is encoded by the NACC1 gene.

Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.

CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene.

Zinc fingers and homeoboxes protein 3 is a protein that in humans is encoded by the ZHX3 gene.

NGFI-A-binding protein 1 is a protein that in humans is encoded by the NAB1 gene.

DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene.

Prolyl 4-hydroxylase subunit alpha-2 is an enzyme that in humans is encoded by the P4HA2 gene.

Zinc finger and BTB domain-containing protein 32 is a protein that in humans is encoded by the 1960 bp ZBTB32 gene. The 52 kDa protein is a transcriptional repressor and the gene is expressed in T and B cells upon activation, but also significantly in testis cells. It is a member of the Poxviruses and Zinc-finger (POZ) and Krüppel (POK) family of proteins, and was identified in multiple screens involving either immune cell tumorigenesis or immune cell development.

Zinc transporter ZIP6 is a protein that in humans is encoded by the SLC39A6 gene.

Zinc finger and BTB domain-containing protein 20 is a protein that in humans is encoded by the ZBTB20 gene.

Zinc finger protein 7 is a protein that in humans is encoded by the ZNF7 gene.

Zinc finger protein 22 is a protein that in humans is encoded by the ZNF22 gene.

Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene.

Zinc finger protein 224 is a protein that in humans is encoded by the ZNF224 gene.

Kruppel-like factor 7 (ubiquitous), also known as KLF7, is a protein which in humans is encoded by the KLF7 gene.

Zinc finger and BTB domain-containing protein 40 is a protein that in humans is encoded by the ZBTB40 gene.

Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160685 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028042 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Widom RL, Culic I, Lee JY, Korn JH (Dec 1997). "Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression". Gene. 198 (1–2): 407–20. doi:10.1016/S0378-1119(97)00360-0. PMID 9370309.
↑ Galera P, Musso M, Ducy P, Karsenty G (Oct 1994). "c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin". Proc Natl Acad Sci U S A. 91 (20): 9372–6. Bibcode:1994PNAS...91.9372G. doi: 10.1073/pnas.91.20.9372 . PMC 44814 . PMID 7937772.
1 2 "Entrez Gene: ZBTB7B zinc finger and BTB domain containing 7B".

External links

ZBTB7B+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000160685 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028042 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9370309-5] Widom RL, Culic I, Lee JY, Korn JH (Dec 1997). "Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression". Gene. 198 (1–2): 407–20. doi:10.1016/S0378-1119(97)00360-0. PMID 9370309.

[pmid7937772-6] Galera P, Musso M, Ducy P, Karsenty G (Oct 1994). "c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin". Proc Natl Acad Sci U S A. 91 (20): 9372–6. Bibcode:1994PNAS...91.9372G. doi: 10.1073/pnas.91.20.9372 . PMC 44814 . PMID 7937772.

[entrez-7] 1 2 "Entrez Gene: ZBTB7B zinc finger and BTB domain containing 7B".

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ZBTB7B

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