Regional presidents

January

• 5 January – Sara Alba is dismissed as Minister of Health of La Rioja in the Government of Concha Andreu. ^[2]
• 19 January – Six people are killed in a fire at a nursing home in Moncada, Valencia. ^[3]

February

• 13 February - The far-right Vox party comes third in the 2022 Castilian-Leonese regional election, raising its representation from 1 up to 13 seats, and becoming the key player for the rival People's Party (PP), who won the elections, to form a government. ^{[4] [5]} Following this election result, and an unfolding leadership crisis in PP, ^[6] Vox for the first time was recognized as the Spain's second political force, according to some opinion polls for the next general elections. ^[7]

March

• 10 March - Vox forms a government with the People's Party in Castile and León, taking three of ten ministerial positions including vice president for regional leader Juan García-Gallardo. This is the first time that Vox forms a part of a government in Spain and the first time that a far-right party is in government since the 1970s. ^[8] Vox member Carlos Pollán was elected President of the Cortes of Castile and León, the position of speaker. ^[9]

May

• 6 May - 2022 Madrid explosion: Two people are killed and eighteen others are injured after a gas leak-caused explosion in Madrid.

June

• 13 June - Vila-seca train crash
• 28–30 June - 2022 NATO Madrid summit

August

• 1 August - Spain is alongside Portugal who both transition to the endemic phase.

October

• 16 October - At least seven people are injured in a suspected gas explosion at a Japanese restaurant in Tarragona, Spain. ^[10]