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WNK3
Identifiers
Aliases	WNK3 , PRKWNK lysine deficient protein kinase 3
External IDs	OMIM: 300358; MGI: 2652875; HomoloGene: 32493; GeneCards: WNK3; OMA:WNK3 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	54,358,642 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	150,103,148 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; buccal mucosa cell; ; tail of epididymis; ; testicle; ; gonad; ; caput epididymis; ; secondary oocyte; ; seminal vesicula; ; internal globus pallidus; ; retinal pigment epithelium;
	Top expressed in
	hand; ; lateral hypothalamus; ; lumbar subsegment of spinal cord; ; ventromedial nucleus; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; anterior amygdaloid area; ; tail of embryo; ; mammillary body; ; lateral septal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; protein kinase activity ; nucleotide binding ; kinase activity ; protein serine/threonine kinase activity ; protein binding ; chloride channel inhibitor activity ; ATP binding ; potassium channel inhibitor activity ;
Cellular component	cytoplasm ; bicellular tight junction ; adherens junction ; cytosol ;
Biological process	phosphorylation ; negative regulation of apoptotic process ; protein phosphorylation ; positive regulation of ion transmembrane transporter activity ; positive regulation of peptidyl-threonine phosphorylation ; positive regulation of sodium ion transport ; protein autophosphorylation ; positive regulation of sodium ion transmembrane transporter activity ; negative regulation of pancreatic juice secretion ; positive regulation of calcium ion transport ; intracellular signal transduction ; regulation of calcium ion import ; protein localization to plasma membrane ; positive regulation of protein localization to plasma membrane ; ion homeostasis ; negative regulation of sodium ion transport ; positive regulation of potassium ion import across plasma membrane ;
	Sources:Amigo / QuickGO
Orthologs
	65267
	279561
	ENSG00000196632
	ENSMUSG00000041245
	Q9BYP7
	Q80XP9
	NM_001002838 ; NM_020922 ; NM_001395166
	NM_001271678 ; NM_001271679
	NP_001002838 ; NP_065973
	NP_001258607 ; NP_001258608
	Wikidata
View/Edit Human	View/Edit Mouse

WNK3

Last updated July 18, 2025

Serine/threonine-protein kinase WNK3, also known as protein kinase lysine-deficient 3, is a protein that in humans is encoded by the WNK3 gene.^[5]

Function

WNK3 is a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca²⁺ transport pathway, and it plays a role in the increase of cell survival in a caspase 3 dependent pathway.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196632 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041245 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: WNK lysine deficient protein kinase 3".

Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286 . PMID 15772651.
Nagase T, Kikuno R, Nakayama M, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi: 10.1093/dnares/7.4.271 . PMID 10997877.
Yang CL, Zhu X, Ellison DH (2007). "The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex". J. Clin. Invest. 117 (11): 3403–11. doi:10.1172/JCI32033. PMC 2045602 . PMID 17975670.
Rinehart J, Kahle KT, de Los Heros P, et al. (2005). "WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl⁻ cotransporters required for normal blood pressure homeostasis". Proc. Natl. Acad. Sci. U.S.A. 102 (46): 16777–82. Bibcode:2005PNAS..10216777R. doi: 10.1073/pnas.0508303102 . PMC 1283841 . PMID 16275913.
Ko B, Hoover RS (2009). "Molecular physiology of the thiazide-sensitive sodium-chloride cotransporter". Curr. Opin. Nephrol. Hypertens. 18 (5): 421–7. doi:10.1097/MNH.0b013e32832f2fcb. PMC 2947818 . PMID 19636250.
San-Cristobal P, Ponce-Coria J, Vázquez N, et al. (2008). "WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na⁺-Cl⁻ cotransporter". Am. J. Physiol. Renal Physiol. 295 (4): F1199-206. doi:10.1152/ajprenal.90396.2008. PMC 2576145 . PMID 18701621.
Glover M, Zuber AM, O'Shaughnessy KM (2009). "Renal and brain isoforms of WNK3 have opposite effects on NCCT expression". J. Am. Soc. Nephrol. 20 (6): 1314–22. doi:10.1681/ASN.2008050542. PMC 2689907 . PMID 19470686.
Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.
Kahle KT, Ring AM, Lifton RP (2008). "Molecular physiology of the WNK kinases". Annu. Rev. Physiol. 70: 329–55. doi:10.1146/annurev.physiol.70.113006.100651. PMID 17961084.
Zhang W, Na T, Peng JB (2008). "WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway". Am. J. Physiol. Renal Physiol. 295 (5): F1472-84. doi:10.1152/ajprenal.90229.2008. PMC 2584897 . PMID 18768590.
Veríssimo F, Silva E, Morris JD, et al. (2006). "Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway". Oncogene. 25 (30): 4172–82. doi:10.1038/sj.onc.1209449. PMID 16501604. S2CID 20133914.
Moniz S, Jordan P (2010). "Emerging roles for WNK kinases in cancer". Cell. Mol. Life Sci. 67 (8): 1265–76. doi:10.1007/s00018-010-0261-6. PMC 11115774 . PMID 20094755. S2CID 32790065.
Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832 . PMID 19913121.
Qiao Y, Liu X, Harvard C, et al. (2008). "Autism-associated familial microdeletion of Xp11.22". Clin. Genet. 74 (2): 134–44. doi:10.1111/j.1399-0004.2008.01028.x. PMID 18498374. S2CID 22008997.
Wilson FH, Disse-Nicodème S, Choate KA, et al. (2001). "Human hypertension caused by mutations in WNK kinases". Science. 293 (5532): 1107–12. doi:10.1126/science.1062844. PMID 11498583. S2CID 22700809.
Heise CJ, Xu BE, Deaton SL, et al. (2010). "Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members". J. Biol. Chem. 285 (33): 25161–7. doi: 10.1074/jbc.M110.103432 . PMC 2919078 . PMID 20525693.
Holden S, Cox J, Raymond FL (2004). "Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3)". Gene. 335: 109–19. doi:10.1016/j.gene.2004.03.009. PMID 15194194.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Veríssimo F, Jordan P (2001). "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms". Oncogene. 20 (39): 5562–9. doi:10.1038/sj.onc.1204726. PMID 11571656. S2CID 24494637.
Bailey SD, Xie C, Do R, et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168 . PMID 20628086.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196632 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041245 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: WNK lysine deficient protein kinase 3".

[1]

[2]

[3]

[4]

[5]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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WNK3

Contents

Function

References

Further reading