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Theoharis C. Theoharides

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Theoharis C. Theoharides (born February 11, 1950 [1] ) is a Greek-American physician-scientist whose research focuses on mast cell biology, neuroimmune interactions, and neuroinflammation. He is a professor at Nova Southeastern University, where he serves as Vice Chair of Clinical Immunology and Executive Director of the Institute for Neuro-Immune Medicine. [2]

Contents

Early life and education

Theoharides was born in Thessaloniki, Greece. He attended Anatolia College before studying at Yale University, where he obtained a B.A. in Biology and History of Medicine, then M.S., M.Phil., Ph.D. in Pharmacology, and finally an M.D. in 1983. [3] He completed training in internal medicine at the New England Medical Center. [4]

Academic and professional career

At Nova Southeastern University, Theoharides is Vice Chair of Clinical Immunology and Executive Director of the Institute for Neuro-Immune Medicine. [2] He also holds an adjunct professorship in immunology at Tufts University School of Medicine, where he previously served as Professor and Director of the Laboratory of Molecular Immunopharmacology & Drug Discovery. [2] [5]

He served as Clinical Pharmacologist for the Massachusetts Drug Formulary Commission from 1983 to 2022. [2] [6]

Research

Theoharides' research explores how mast cells selectively release mediators and interact with microglia, influence blood–brain barrier permeability, and contribute to neuroinflammation in conditions such as autism spectrum disorder, [7] [8] multiple sclerosis, chronic fatigue syndrome, and Long COVID. [9]

He has published reviews such as Recent advances in our understanding of mast cell activation (2019) discussing mast cell roles in inflammation. [10]

In Mast cells in the autonomic nervous system and potential role in disorders with dysautonomia and neuroinflammation (2024), he examined mast cell interfaces with autonomic dysfunction. [11]

He also reviewed the relationship between psychological stress and mast cell activation (2020). [12]

In the autism field, a collaborative study reported reduced cytokine levels among children with autism spectrum disorders who received a luteolin-containing formulation. [13]

In peripheral inflammation studies, Genitourinary mast cells and survival addressed mast cell roles in bladder pain and interstitial cystitis. [14]

He is principal investigator of a project on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) examining how extracellular vesicles from patients may influence mast cell and microglial activation. [15]

During the COVID-19 pandemic, he coauthored Successful Treatment of a Patient With Severe COVID-19 discussing mast cell–modulating therapeutic considerations. [16]

Patents and product development

According to his curriculum vitae, Theoharides holds over 30 patents in immunology and mast cell biology. [4] He is associated with Algonot LLC, which markets flavonoid-based formulations containing luteolin and related compounds. [17]

Selected publications

Recognition and impact

His university biography states he has authored over 500 peer-reviewed publications. [4] His work is cited in numerous reviews on mast cell activation and neuroimmunology, and his ongoing projects in ME/CFS and dysautonomia reflect continuing research activity.

See also

References

  1. ↑ "1 Curriculum Vitae Theoharis C. Theoharides" (PDF). assets-global.website-files.com. Retrieved 20 January 2026.
  2. 1 2 3 4 "Theoharis C. Theoharides". Nova Southeastern University. Retrieved 2025-10-10.
  3. ↑ Training, American Chemical Society Committee on Professional (2005). Directory of Graduate Research. American Chemical Society. p. 1672. Retrieved 20 January 2026.
  4. 1 2 3 "Theoharis C. Theoharides, BA, MS, MPhil, PhD, MD, FAAAAI". Nova Southeastern University. Retrieved 2025-10-10.
  5. ↑ Dale, Connor (February 6, 2020). "Professors sue Tufts over new compensation, lab space policies". The Tufts Daily. Retrieved 20 January 2026.
  6. ↑ "Members of the Massachusetts Drug Formulary Commission". Mass.gov. Retrieved 2025-10-10.
  7. ↑ Varia, J; Herbert, M; Hooker, B (20 December 2025). "The Neuroimmunology of Autism". Molecular Neurobiology. 63 (1): 316. doi:10.1007/s12035-025-05589-8. PMC   12718276 . PMID   41420751.
  8. ↑ Varricchi, G; Marone, G (11 January 2020). "Mast Cells: Fascinating but Still Elusive after 140 Years from Their Discovery". International Journal of Molecular Sciences. 21 (2): 464. doi: 10.3390/ijms21020464 . PMC   7013937 . PMID   31940755.
  9. ↑ Tandon, P; Abrams, ND; Avula, LR; Carrick, DM; Chander, P; Divi, RL; Dwyer, JT; Gannot, G; Gordiyenko, N; Liu, Q; Moon, K; PrabhuDas, M; Singh, A; Tilahun, ME; Satyamitra, MM; Wang, C; Warren, R; Liu, CH (15 February 2024). "Unraveling Links between Chronic Inflammation and Long COVID: Workshop Report". The Journal of Immunology. 212 (4): 505–512. doi:10.4049/jimmunol.2300804. ISSN   0022-1767. PMID   38315950.
  10. ↑ Theoharides, T. C. (2019). "Recent advances in our understanding of mast cell activation". Clinical and Molecular Allergy. 17 (24). doi: 10.1177/1178223419883833 . PMC   6804360 . PMID   31673226.
  11. ↑ Theoharides, T. C. (2024). "Mast cells in the autonomic nervous system and potential role in disorders with dysautonomia and neuroinflammation". Annals of Allergy, Asthma & Immunology. 11 (8): 2327–2329. doi:10.1016/j.jaip.2023.06.034. PMID   37393005.
  12. ↑ Theoharides, T. C. (2020). "The impact of psychological stress on mast cells". Annals of Allergy, Asthma & Immunology. 125 (3): 334–340.e1. doi:10.1016/j.anai.2020.05.015. PMID   32445670.
  13. ↑ Tsilioni, I.; Taliou, A.; Francis, K.; Theoharides, T. C. (2015). "Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6". Translational Psychiatry. 5 (9): 1413–1416. doi:10.1038/tp.2015.142. PMC   4529256 . PMID   26346840.
  14. ↑ Theoharides, T. C. (2015). "Genitourinary mast cells and survival". Translational Andrology and Urology. 4 (5): 57986–115486. doi:10.3978/j.issn.2223-4683.2015.10.04. PMC   4708553 . PMID   26813805 . Retrieved 2025-10-10.
  15. ↑ "Theoharis Theoharides – Solve M.E. Researcher Page". Solve M.E. Retrieved 2025-10-10.
  16. ↑ Theoharides, T. C. (2022). "Successful Treatment of a Patient With Severe COVID-19". Diagnostics. 12 (5): 1128. doi: 10.3390/diagnostics12051128 . PMC   9145307 . PMID   35631386.
  17. ↑ "Algonot LLC". Algonot. Retrieved 2025-10-10.
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