Argentina

• San Antonio, Arauco, a municipality and village in La Rioja Province
• San Antonio de Areco, a city in Buenos Aires Province
• Cape San Antonio, Argentina, a cape on the eastern coast of Buenos Aires Province
• San Antonio de los Cobres, a town in Salta Province
• San Antonio, Fray Mamerto Esquiú, a municipality in Catamarca Province
• San Antonio, General Juan Facundo Quiroga, a municipality and village in La Rioja Province
• San Antonio, Jujuy, a town and municipality in Jujuy Province
• San Antonio, Misiones, a city in Misiones Province
• San Antonio, Santa Fe, a locality in Santa Fe Province
• San Antonio Department, Río Negro
• San Antonio Oeste, a port city in Río Negro Province
• San Antonio, Paclín, a village and municipality in Catamarca Province
• San Antonio de La Paz, a village and municipality in Catamarca Province

Belize

• San Antonio, a village in Corozal District
• San Antonio, a village in Orange Walk District
• San Antonio, Cayo, a village in the Cayo District
• San Antonio, Toledo, a village in the Toledo District

Chile

• San Antonio, Chile, the capital of the San Antonio Province
• San Antonio Province, one of eight provinces of the central Chilean region of Valparaíso

Colombia

• Capilla de San Antonio (Cali)  [ es ], a national monument in Santiago de Cali, Colombia
• Cerro San Antonio, a town and municipality of the department of Magdalena
• San Antonio, Tolima, a municipality in the department of Tolima
• San Antonio del Tequendama, a municipality and town of the department of Cundinamarca
• San Antonio, Buenaventura, village in Buenaventura Municipality, Valle del Cauca Department
• San Antonio (Medellín), a station on the Medellín Metro, Medellín, Colombia
• San Antonio, Tolima, a municipality in Colombia

Cuba

• San Antonio de los Baños, a municipality and town in Artemisa Province
• San Antonio del Sur, a municipality and town in the Guantánamo Province
• Cape San Antonio, Cuba, a cape which forms the western extremity of the Guanahacabibes Peninsula

Guatemala

• San Antonio Aguas Calientes, a municipality in the department of Sacatepéquez
• San Antonio Huista, a municipality in the department of Huehuetenango
• San Antonio Ilotenango, a municipality in the department of El Quiché
• San Antonio La Paz, a municipality in the department of El Progreso
• San Antonio Palopó, a municipality in the department of Sololá
• San Antonio Sacatepéquez, a municipality in the department of San Marcos
• San Antonio Suchitepéquez, a municipality in the department of Suchitepéquez
• San Antonio Sija, a municipality in the department of Totonicapan

Honduras

• San Antonio de Cortés, a municipality in the department of Cortés Department
• San Antonio, Copán, a municipality in the department of Copán
• San Antonio, Intibucá, a municipality in the department of Intibucá

Mexico

Paraguay

• San Antonio, Paraguay, a city in the Central Department
• San Antonio (Asunción), a neighbourhood of Asunción

Peru

• San Antonio District, Cañete
• San Antonio District, Huarochirí
• San Antonio de Putina Province in the Puno region
• San Antonio River (Peru)

Philippines

• San Antonio, Northern Samar, a municipality in Northern Samar
• San Antonio, Nueva Ecija, a municipality in Nueva Ecija
• San Antonio, Quezon, a municipality in Quezon
• San Antonio, Zambales, a municipality in Zambales
• San Antonio, Gandara, Samar, a barangay in Samar
• San Antonio, Parañaque, a barangay in Metro Manila
• San Antonio, Quezon City, a barangay in Metro Manila
• San Antonio, San Jose, Camarines Sur, a barangay in Camarines Sur
• San Antonio, San Pedro, a barangay in Laguna
• San Antonio, Santo Tomas, Batangas, a barangay in Batangas

Spain

• Cape San Antonio, Spain, a cape on the north coast of Alicante province, Spain
• San Antonio (Requena), a village in Valencia, Spain
• Sant Antoni de Portmany, a town in Ibiza, Spain

United States

Uruguay

• Cerro San Antonio, a hill in the Maldonado Department
• San Antonio, Canelones, a village in the Canelones Department
• San Antonio, Rocha, a seaside resort in the Rocha Department
• San Antonio, Salto, a suburb of Salto in the Salto Department

Other places

• San Antonio Lake (Bolivia), a lake in Bolivia
• Santo Antônio do Sudoeste, a municipality in Paraná State, Brazil
• San Antonio, El Salvador, a municipality in El Salvador
• San Antonio de Palé (formerly "San Antonio de Praia"), the capital of Annobón, an island in Equatorial Guinea
• San Antonio, Saipan, a settlement in the Mariana Islands
• San Antonio, Panama, in Veraguas Province, Panama
• San Antonio (Poschiavo), a municipality in the canton of Grisons, Switzerland
• San Antonio del Táchira, a city in the Venezuelan Andean state of Táchira, Venezuela
• San Antonio District, a district in the canton of Atenas, Costa Rica