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Phycocyanobilin:ferredoxin oxidoreductase

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phycocyanobilin:ferredoxin oxidoreductase
Identifiers
EC no. 1.3.7.5
CAS no. 347401-12-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, phycocyanobilin:ferredoxin oxidoreductase (PcyA, EC 1.3.7.5) is an enzyme that catalyzes the chemical reaction

+ 4 reduced
ferredoxin
 
 
 
 
Phycocyanobilin:ferredoxin oxidoreductase
 
 
 
+ 4 oxidised
ferredoxin
 

The two substrates of this enzyme are biliverdin and reduced ferredoxin. Its products are (2R,3Z)-phycocyanobilin and oxidized ferredoxin. [1] [2] [3] [4]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is (3Z)-phycocyanobilin:ferredoxin oxidoreductase. This enzyme participates in the catabolism of heme. [2]

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2D1E, 2DKE, and 2G18.

References

  1. Enzyme 1.3.7.5 at KEGG Pathway Database.
  2. 1 2 Beale, Samuel I. (1993). "Biosynthesis of phycobilins". Chemical Reviews. 93 (2): 785–802. doi:10.1021/cr00018a008.
  3. Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC (2001). "Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms". Plant Cell. 13 (4): 965–78. Bibcode:2001PlanC..13..965F. doi:10.1105/tpc.13.4.965. PMC   135530 . PMID   11283349.
  4. Wu SH, McDowell MT, Lagarias JC (1997). "Phycocyanobilin is the natural precursor of the phytochrome chromophore in the green alga Mesotaenium caldariorum". J. Biol. Chem. 272 (41): 25700–5. doi: 10.1074/jbc.272.41.25700 . PMID   9325294.


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