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Paul E. Love
Alma mater	Syracuse University University of Rochester School of Medicine
Known for	T cell antigen receptor signaling Immuno-receptor-tyrosine based activation motifs (ITAMs) Mammalian T cell development
Scientific career
Fields	Immunology Developmental Biology
Institutions	National Institutes of Health

Paul Ernest Love is an American physician and Immunologist. He is a senior investigator and head of the Section on Hematopoiesis and Lymphocyte Biology at Eunice Kennedy Shriver National Institute of Child Health and Human Development. His research focus is in the area of mammalian hematopoiesis.

Contents

• Education
• Career
• Selected publications
• References

Education

Love earned his B.S. in biochemistry, summa cum laude, from Syracuse University. ^[1] He received his M.D. and a Ph.D. in the MSTP program at the University of Rochester. ^[2]

Career

Love started his career as an intramural Principal Investigator in 1993 and is now a tenured senior investigator at NICHD. ^[3] He was a commissioned officer in the United States Public Health Service from 1989 to 2019 and retired with the rank of captain in 2019.

His lab is part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and investigates T cell development.

Love and his colleagues have conducted studies on several aspects of mammalian T cell development including the role of T cell antigen receptor (TCR) signaling and the role of the newly identified molecule, THEMIS (protein), in T cell development and for T cell function. ^[4]

Selected publications

• Love, Paul; Lesourne, Renaud; Argenty, Jérémy; Lee, Jan; Zvezdova, Ekaterina; Warzecha, Claude; Choi, Seeyoung (2017). "THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1". Nature Immunology . 18 (4): 433–441. doi:10.1038/ni.3692. PMC   5807080 . PMID   28250424.
• Love, Paul; Shores, E W (2000). "ITAM multiplicity and thymocyte selection: how low can you go?". Immunity . 12 (6): 591–597. doi: 10.1016/s1074-7613(00)80210-1 . PMID   10894159.
• Love, Paul; Zhao, Bin; Dutta, Avik (2021). "New insights into TCR β-selection". Trends Immunol . 42 (8): 735–750. doi:10.1016/j.it.2021.06.005. PMID   34261578. S2CID   235907092.
• Love, Paul; Shores, E W (1997). "TCR zeta chain in T cell development and selection". Curr Opin Immunol . 9 (3): 380–389. doi:10.1016/s0952-7915(97)80085-4. PMID   9203416.
• Full list of publications: https://pubmed.ncbi.nlm.nih.gov/?term=love+pe&sort=pubdate&size=200

References