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Nicotine blue oxidoreductase

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Nicotine blue oxidoreductase
Identifiers
EC no. 1.1.1.328
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
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PMC articles
PubMed articles
NCBI proteins

Nicotine blue oxidoreductase (EC 1.1.1.328, nboR (gene)) is an enzyme with systematic name 3,3'-bipyridine-2,2',5,5',6,6'-hexol:NADP+ 11-oxidoreductase. [1] This enzyme catalyses the following chemical reaction

+ NAD+
 
 
 
H+
Nicotine blue oxidoreductase
 
H+
 
+ NADH
 

The enzyme can use the alternative cofactor, nicotinamide adenine dinucleotide phosphate. [2] It is extracted from the bacterium Arthrobacter nicotinovorans . [1]

References

  1. 1 2 Mihasan M, Chiribau CB, Friedrich T, Artenie V, Brandsch R (April 2007). "An NAD(P)H-nicotine blue oxidoreductase is part of the nicotine regulon and may protect Arthrobacter nicotinovorans from oxidative stress during nicotine catabolism". Applied and Environmental Microbiology. 73 (8): 2479–85. Bibcode:2007ApEnM..73.2479M. doi:10.1128/AEM.02668-06. PMC   1855579 . PMID   17293530.
  2. Enzyme 1.1.1.328 at KEGG Pathway Database.
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