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Nafithromycin

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Nafithromycin
Nafithromycin structure.png
Clinical data
Other namesWCK-4873
ATC code
Identifiers
  • (1S,2R,5R,7R,8R,9R,11R,13R,14S,15R)-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,6,12,16-tetraoxo-N'-[(1S)-1-(5-pyridin-2-yl-1,3,4-thiadiazol-2-yl)ethoxy]-3,17-dioxabicyclo[12.3.0]heptadecane-15-carboximidamide
CAS Number
PubChem CID
UNII
Chemical and physical data
Formula C42H62N6O11S
Molar mass 859.05 g·mol−1
3D model (JSmol)
  • CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)[C@@H](C(=O)O2)/C(=N/O[C@@H](C)C4=NN=C(S4)C5=CC=CC=N5)/N)C
  • InChI=1S/C42H62N6O11S/c1-13-28-42(9)30(29(39(53)58-42)35(43)47-59-25(7)36-45-46-37(60-36)26-16-14-15-17-44-26)22(4)31(49)20(2)19-41(8,54-12)34(23(5)32(50)24(6)38(52)56-28)57-40-33(51)27(48(10)11)18-21(3)55-40/h14-17,20-25,27-30,33-34,40,51H,13,18-19H2,1-12H3,(H2,43,47)/t20-,21-,22-,23+,24-,25+,27+,28-,29-,30+,33-,34-,40+,41-,42-/m1/s1
  • Key:RLFCSBSRGRJFRO-QAOQTAGDSA-N

Nafithromycin is an experimental antibiotic medication for the treatment of pneumonia. [1] [2]

References

  1. ↑ Iwanowski P, Bhatia A, Gupta M, Patel A, Chavan R, Yeole R, et al. (September 2019). "Safety, tolerability and pharmacokinetics of oral nafithromycin (WCK4873) after single or multiple doses and effects of food on single-dose bioavailability in healthy adult subjects". Antimicrobial Agents and Chemotherapy. 63 (12). doi:10.1128/AAC.01253-19. PMC   6879255 . PMID   31591119.
  2. ↑ Sellarès-Nadal J, Burgos J, Falcó V, Almirante B (2020). "Investigational and Experimental Drugs for Community-Acquired Pneumonia: the Current Evidence". Journal of Experimental Pharmacology. 12: 529–538. doi: 10.2147/JEP.S259286 . PMC   7682597 . PMID   33239925.
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