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N-sulfoglucosamine-3-sulfatase

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N-sulfoglucosamine-3-sulfatase
Identifiers
EC no. 3.1.6.15
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NCBI proteins

The enzyme N-sulfoglucosamine-3-sulfatase (EC 3.1.6.15}) catalyzes cleaving off the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin. [1] [2]

This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic name is N-sulfo-3-sulfoglucosamine 3-sulfohydrolase. This enzyme is also called chondroitinsulfatase. This enzyme participates in the degradation of glycan structures.

References

  1. ↑ Bruce JS, McLean MW, Long WF, Williamson FB (1985). "Flavobacterium heparinum 3-O-sulphatase for N-substituted glucosamine 3-O-sulphate". Eur. J. Biochem. 148 (2): 359–65. doi:10.1111/j.1432-1033.1985.tb08847.x. PMID   3987694.
  2. ↑ Leder IG (1980). "A novel 3-O sulfatase from human urine acting on methyl-2-deoxy-2-sulfamino-alphs-D-glucopyranoside 3-sulfate". Biochem. Biophys. Res. Commun. 94 (4): 1183–9. Bibcode:1980BBRC...94.1183L. doi:10.1016/0006-291X(80)90544-6. PMID   7396957.


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