Given name

• Melisa Abimbola, a British–Nigerian Afropop singer and songwriter
• Melisa Akarsu (born 1993), a Turkish swimmer competing in the butterfly events
• Melisa Arévalo (born 1980), an Argentine former professional tennis player
• Melisa Bester, a South African-born Australian singer-songwriter and musician
• Melai Cantiveros (born 1988; Melisa Bunayog Cantiveros-Francisco), a Filipino comedian, television personality and actress
• Melisa Dilber Ertürk (born 1993), a women's football midfielder playing in Canada and the United States
• Melisa Döngel (born 1999), a Turkish actress and model
• Mel Filis (born 2002; Melisa Katie Filis), a professional footballer who plays as a midfielder
• Melisa López Franzen (born 1980), an American politician and former member of the Minnesota Senate
• Melisa Gil (born 1984), an Argentine sports shooter
• Melisa Gretter (born 1993), an Argentine basketball player for Campinas Basquete Clube and the Argentina women's national basketball team
• Melisa Güneş (born 2001), a Turkish weightlifter competing in the women's –45 kg division
• Melisa Hasanbegović (born 1995), a Bosnian football defender who plays for SC Braga
• Melisa Kerman (born 1994), a Turkish female volleyball player
• Melisa Matheus (born 1998), a Namibian footballer who plays as a goalkeeper
• Melisa C. Michaels (1946–2019), an American science fiction and mystery author
• Melisa Miranda-Otarola (born 1988), a Chilean former professional tennis player
• Melisa Moses (born 1972), a former American diver
• Melisa Murillo (born 1982), a retired Colombian athlete who specialised in sprinting events
• Melisa Nicolau (born 1984), a Spanish former footballer, who played as a defender for Primera División clubs Rayo Vallecano and FC Barcelona
• Melisa Ramos (born 1997; Melisa Alejandra Ramos Pérez), a Mexican professional footballer
• Melisa Rollins (born 1995), an American professional racing cyclist who placed 5th at the Unbound 200 mile gravel race in 2022
• Melisa Şenolsun (born 1996), a Turkish actress
• Melisa Sözen (born 1985), a Turkish actress
• Melisa Upu (born 1974), a New Zealand softball player
• Melisa Wallack, an American screenwriter and film director
• Melisa Aslı Yazıcı, a Dutch-Turkish actress, model and beauty pageant titleholder
• Melisa Zhdrella (born 2000), a Kosovan swimmer