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Madhusoodan V. Hosur

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Madhusoodan V. Hosur
Prof MV Hosur.png
Born (1950-12-24) 24 December 1950 (age 75) [1]
India
Alma mater
Known forStructural studies of HIV-1 protease; Viral protein crystallography; Drug design research
Awards
Scientific career
Fields
Institutions

Madhusoodan Vijayacharya Hosur (born 24 December 1950) also known as MV Hosur is an Indian structural biologist and crystallographer known for his work on macromolecular crystallography, including viral and HIV-1 protease structures, and for contributions to drug-design research.

Contents

Early life and education

He received his Ph.D. in X-ray crystallography of nucleotides, coenzymes and high-energy phosphates from the Indian Institute of Science (IISc), Bengaluru, India during (1973–1979). [2] [3]

He then carried out early work as a Research Associate, University of Wisconsin–Madison (1979–1981), on the X-ray crystallography of oligonucleotides. Later he worked at the Purdue University (1982–1986) on the X-ray structure of spherical viruses. [4] [1]

Career

He joined BARC, Mumbai, as Scientific Officer in 1986 and stayed there until 1999 on the work related to macromolecular crystallography and drug‐design. [5]

From 1999 to 2012, he was with the Protein Crystallography Section, Solid-State Physics Division (SSPD) at BARC as head. His work was focused on viral protein structures, malaria proteins, and drug-resistance mechanisms. Later he moved to the Advanced Centre for Treatment Research and Education in Cancer (ACTREC) in Navi Mumbai, continuing his research in biophysics, crystallography, and big-data epilepsy from 2013 to 2016. [6] [7]

From 2017 onward, he has been an INSA-Senior scientist [8] and holding adjunct professorship at the National Institute of Advanced Studies, Bangalore. He focuses on big-data approaches in epilepsy and other biomedical fields. [1] [9]

Awards and honours

Selected Bibliography

References

  1. 1 2 3 "Madhusoodan Hosur". cms.nias.res.in. National Institute of Advanced Studies . Retrieved 15 November 2025.
  2. ↑ Kannan, K. K. (1995). "India". World Directory of Crystallographers. pp. 80–87. doi:10.1007/978-94-017-3699-2_29. ISBN   978-0-7923-3180-3.
  3. ↑ Viswamitra, M. A.; Hosur, M. V.; Shakked, Zippora; Kennard, Olga (July 1976). "X-ray study of the rubidium salt of ADP". Nature. 262 (5565): 234–236. Bibcode:1976Natur.262..234V. doi:10.1038/262234a0. PMID   934342.
  4. ↑ Zhang, X; Sun, S; Xiang, Y; Wong, J; Klose, T; Raoult, D; Rossmann, MG (6 November 2012). "Structure of Sputnik, a virophage, at 3.5-Å resolution". Proceedings of the National Academy of Sciences of the United States of America. 109 (45): 18431–6. Bibcode:2012PNAS..10918431Z. doi: 10.1073/pnas.1211702109 . PMC   3494952 . PMID   23091035.
  5. ↑ "Form and Function of Biomolecules Macromolecular crystallography in India | Historical Profile through Publications (1981–2015)" (PDF). mbu.iisc.ac.in. Molecular Biophysics Unit, Indian Institute of Science . Retrieved 15 November 2025.
  6. ↑ Raskar, Tushar; Khavnekar, Sagar; Hosur, Madhusoodan (30 August 2016). "Time-dependent X-ray diffraction studies on urea/hen egg white lysozyme complexes reveal structural changes that indicate onset of denaturation". Scientific Reports. Vol. 6. doi:10.1038/srep32277.
  7. ↑ "MV Hosur | Profile" (PDF). cms.nias.res.in. National Institute of Advanced Studies . Retrieved 15 November 2025.
  8. ↑ "Sectional Committees-2020 | Delhi" (PDF). insaindia.res.in. Indian National Science Academy . Retrieved 15 November 2025.
  9. ↑ Kumar, Arvind; Janaki, Chintalapati; Hosur, M. V.; Pal, Supriya N. (20 December 2020). "Machine Learning techniques to identify potential drug targets for Anti-epileptic drugs". 2020 IEEE International Conference on Machine Learning and Applied Network Technologies (ICMLANT). pp. 1–6. doi:10.1109/ICMLANT50963.2020.9355971. ISBN   978-1-7281-8885-0.
  10. ↑ "INSA :: Fellow Detail (P10-1511)". insajournal.in. Indian National Science Academy . Retrieved 15 November 2025.
  11. ↑ Kumar, M; Prashar, V; Mahale, S; Hosur, MV (15 July 2005). "Observation of a tetrahedral reaction intermediate in the HIV-1 protease-substrate complex". The Biochemical Journal. 389 (Pt 2): 365–71. doi:10.1042/BJ20041804. PMC   1175113 . PMID   15794743.
  12. ↑ "MV Hosur Bio". OPEN SOURCE PHARMA FOUNDATION. Retrieved 15 November 2025.
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