Athletics
- Randy Barnes, Olympic shot put gold and silver medalist
- Brian Bowles, MMA fighter, bantamweight champion
- Kevin Canady, Professional wrestler founder of IWA East Coast
- Dorian Etheridge, linebacker for the Atlanta Falcons
- William Frischkorn, cyclist
- George H. Goodrich, justice, Superior Court of the District of Columbia
- J. R. House, professional baseball player and coach J. R. House
- Hot Rod Hundley, basketball player and broadcaster Hot Rod Hundley
- George King, NBA player and head coach of West Virginia and Purdue
- John Kruk, Former Major League Baseball player and current sportscaster, was born in Charleston, but grew up in Keyser
- Rick Nuzum, National Football League player
- Phil Pfister, world's strongest man (2006), is a firefighter for CFD
- Russ Thomas, NFL player, general manager of Detroit Lions 1967–89
- Anne White, Tennis player, attended John Adams Junior High School and graduated from George Washington High School.
- Jason Williams, Miami Heat point guard, who grew up in Belle in the same vicinity, was a high school teammate of Randy Moss
- Harry Young, Athlete and coach, member of College Football Hall of Fame
- Dennis Harrah, Former NFL player
