The highest-selling digital singles in the United States are ranked in the Hot Digital Songs chart, published by Billboard magazine. The data are compiled by Nielsen SoundScan based on each single's weekly digital sales, which combines sales of different versions of a single for a summarized figure.
| † | Indicates best-charting digital song of 2008 [1] |
| Issue date | Song | Artist(s) | Weekly sales | Ref(s) |
|---|---|---|---|---|
| January 5 | "Low" † | Flo Rida featuring T-Pain | 178,000 | [2] [3] |
| January 12 | 467,000 | [4] [5] | ||
| January 19 | 232,000 | [6] [7] | ||
| January 26 | [8] | |||
| February 2 | 180,000 | [9] [10] | ||
| February 9 | 170,000 | [11] [12] | ||
| February 16 | 179,000 | [13] [14] [15] | ||
| February 23 | 167,000 | [16] [15] [17] | ||
| March 1 | [18] | |||
| March 8 | [19] | |||
| March 15 | "Love in This Club" | Usher featuring Young Jeezy | 198,000 | [20] [21] |
| March 22 | "Hallelujah" | Jeff Buckley | 178,000 | [22] [23] |
| March 29 | "Love in This Club" | Usher featuring Young Jeezy | [24] | |
| April 5 | "Bleeding Love" | Leona Lewis | 219,000 | [25] [26] |
| April 12 | "Touch My Body" | Mariah Carey | 286,000 | [27] [28] |
| April 19 | "4 Minutes" | Madonna featuring Justin Timberlake | 217,000 | [29] [30] |
| April 26 | "Bleeding Love" | Leona Lewis | 223,000 | [31] [32] |
| May 3 | "4 Minutes" | Madonna featuring Justin Timberlake | 202,000 | [33] [34] |
| May 10 | "Bleeding Love" | Leona Lewis | 236,000 | [35] [36] |
| May 17 | 217,000 | [37] [38] | ||
| May 24 | "Take a Bow" | Rihanna | 267,000 | [39] [40] |
| May 31 | 196,000 | [41] [42] | ||
| June 7 | "The Time of My Life" | David Cook | 236,000 | [43] [44] |
| June 14 | "Viva la Vida" | Coldplay | 219,000 | [45] [46] |
| June 21 | 253,000 | [47] [48] | ||
| June 28 | 246,000 | [49] [50] | ||
| July 5 | "I Kissed a Girl" | Katy Perry | 235,000 | [51] [52] |
| July 12 | 206,000 | [53] [54] | ||
| July 19 | 191,000 | [55] [56] | ||
| July 26 | 177,000 | [57] [58] [59] | ||
| August 2 | 166,000 | [60] [61] | ||
| August 9 | 151,000 | [62] [63] | ||
| August 16 | "Disturbia" | Rihanna | 140,000 | [64] [65] |
| August 23 | 148,000 | [66] [67] | ||
| August 30 | "Crush" | David Archuleta | 166,000 | [68] [69] |
| September 6 | "Whatever You Like" | T.I. | 205,000 | [70] [71] |
| September 13 | 176,000 | [72] [73] | ||
| September 20 | "So What" | Pink | 197,000 | [74] [75] |
| September 27 | 253,000 | [76] [77] | ||
| October 4 | 218,000 | [78] [79] | ||
| October 11 | "Whatever You Like" | T.I. | [80] | |
| October 18 | "Live Your Life" | T.I. featuring Rihanna | 335,000 | [81] [82] |
| October 25 | "Womanizer" | Britney Spears | 286,000 | [83] [84] |
| November 1 | 201,000 | [85] [86] | ||
| November 8 | "If I Were a Boy" | Beyoncé | 190,000 | [87] [88] |
| November 15 | "Live Your Life" | T.I. featuring Rihanna | 184,000 | [89] [90] |
| November 22 | "Heartless" | Kanye West | 201,000 | [91] [92] |
| November 29 | "If I Were a Boy" | Beyoncé | 170,000 | [93] [94] |
| December 6 | "Single Ladies (Put a Ring on It)" | 204,000 | [95] [96] | |
| December 13 | 228,000 | [97] [98] | ||
| December 20 | "Circus" | Britney Spears | 212,000 | [99] [100] |
| December 27 | 153,000 | [101] [102] | ||