This is a list of UTSA Roadrunners football players in the NFL draft.
| B | Back | K | Kicker | NT | Nose tackle |
| C | Center | LB | Linebacker | FB | Fullback |
| DB | Defensive back | P | Punter | HB | Halfback |
| DE | Defensive end | QB | Quarterback | WR | Wide receiver |
| DT | Defensive tackle | RB | Running back | G | Guard |
| E | End | T | Offensive tackle | TE | Tight end |
| Year | Round | Pick | Overall | Player | Team | Position |
|---|---|---|---|---|---|---|
| 2016 | 6 | 13 | 188 | David Morgan II | Minnesota Vikings | TE |
| 2018 | 1 | 14 | 14 | Marcus Davenport | New Orleans Saints | DE |
| 2022 | 4 | 29 | 134 | Spencer Burford | San Francisco 49ers | T |
| 5 | 10 | 153 | Riq Woolen | Seattle Seahawks | DB | |
| 2025 | 5 | 33 | 169 | Zah Frazier | Chicago Bears | DB |
Note: No drafts held before 1920
| Debut year | Player name | Position | Debut NFL/AFL team | Notes |
|---|---|---|---|---|
| 2015 | Triston Wade | FS | Seattle Seahawks | |
| 2016 | Jason Neill | DT | Dallas Cowboys | |
| Brian Price | NT | Green Bay Packers | ||
| 2017 | Jarveon Williams | RB | Cincinnati Bengals | |
| 2019 | Kevin Strong | NT | Detroit Lions | |
| Josiah Tauaefa | LB | New York Giants | ||
| 2020 | Eric Banks | DE | Los Angeles Rams | |
| 2022 | Sincere McCormick | RB | Las Vegas Raiders | |
| Leroy Watson | OT | Atlanta Falcons | ||
| 2024 | Joshua Cephus | WR | Jacksonville Jaguars | |
| Brandon Matterson | DE | Denver Broncos | ||
| Rashad Wisdom | S | Tampa Bay Buccaneers | ||