Leslie Z. Benet | |
|---|---|
| Leslie Z. Benet aged 86 | |
| Born | May 17, 1937 (age 88) Cincinnati, Ohio |
| Occupation(s) | Department of Bioengineering and Therapeutic Sciences, School of Pharmacy and Medicine, University of California |
| Title | Professor |
| Spouse | Carol |
| Academic background | |
| Alma mater | UCSF |
| Thesis | Thermodynamics of Chelation by Tetracyclines (1965) |
| Doctoral advisor | Jere Goyan |
| Academic work | |
| Discipline | Pharmacology |
| Sub-discipline | Pharmacokinetics,Pharmacodynamics,Bioequivalence |
| Institutions | Washington State University,University of California |
| Website | pharmacy |
Leslie 'Les' Zachary Benet (born May 17,1937) is an influential pharmaceutical scientist [1] heading the UCSF's Benet Lab at the Department of Bioengineering and Therapeutic Sciences [2] and recipient of the Remington Medal for distinguished service to American pharmacy.
Leslie Zachary Benet was born on May 17,1937,in Cincinnati,Ohio,into a family of pharmacists. His father,Jonas and his uncle,Harry,opened Benet's Pharmacies in Cincinnati in the 1930s and in 1942 founded DARA Products,the first drug company to manufacture hypoallergenic dermatologicals. [3]
Benet received his B.A. (English,1959),B.S. (Pharmacy,1960),M.S. (Pharmaceutical Chemistry,1962) from the University of Michigan and Ph.D. (Pharmaceutical Chemistry,1965) from the University of California. [3]
Benet's early work included noncompartmental methods for calculating clearance and volume of distribution. [4] [5] [6] His paper on the volume of distribution is the most highly cited article in the Journal of Pharmaceutical Sciences (cited more than 900 times out of 19,000 articles). [7] In 1986 he was a founder and first president of the American Association of Pharmaceutical Scientists. [8] For over twenty years,Benet chaired the Department of Pharmacy at the UCSF which,under his leadership,became the Department of Biopharmaceutical Sciences. He supervised more than 55 Ph.D. theses and 100 post-doc students. Benet regularly advised the FDA in proposing guidance in the field of bioequivalence. [9] His recent work extended the Biopharmaceutics Classification System,leading to the Biopharmaceutics Drug Disposition Classification System allowing the prediction of enzymes and transporters,transporter-enzyme interplay and transporter-transporter interplay for new molecular entities and drug-drug interactions for already marketed drugs. [10] [11] Benet is listed as one of the "25 Top Pharmacy Professors" in the USA. [12]
Benet published over 570 articles in peer-reviewed journals,more than 100 book chapters,and seven books.