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LCORL
Identifiers
Aliases	LCORL , MLR1, ligand dependent nuclear receptor corepressor like
External IDs	OMIM: 611799; MGI: 2651932; HomoloGene: 82325; GeneCards: LCORL; OMA:LCORL - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	18,021,876 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	45,857,615 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; endothelial cell; ; sperm; ; jejunal mucosa; ; visceral pleura; ; mucosa of ileum; ; tibia; ; parietal pleura; ; pancreatic ductal cell; ; ventricular zone;
	Top expressed in
	ventromedial nucleus; ; habenula; ; Rostral migratory stream; ; spermatocyte; ; barrel cortex; ; lumbar spinal ganglion; ; anterior amygdaloid area; ; lateral septal nucleus; ; pineal gland; ; epithelium of small intestine;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding ; protein binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	nucleus ;
Biological process	regulation of transcription by RNA polymerase II ; regulation of transcription, DNA-templated ; transcription by RNA polymerase II ; transcription, DNA-templated ;
	Sources:Amigo / QuickGO
Orthologs
	254251
	209707
	ENSG00000178177
	ENSMUSG00000015882
	Q8N3X6
	Q3U285
	NM_001166139 ; NM_153686
NM_001163073 ; NM_172153 ; NM_178142 ; NM_001359871 ; NM_001359872 ;
	NM_001359873 ; NM_001359874
NP_001159611 ; NP_710153 ; NP_001352587 ; NP_001352588 ; NP_001352589 ;
	NP_001352590 ; NP_001352591 ; NP_001352592 ; NP_001352594 Contents Function ; References ; Further reading ;
NP_001156545 ; NP_742165 ; NP_835278 ; NP_001346800 ; NP_001346801 ;
	NP_001346802 ; NP_001346803
	Wikidata
View/Edit Human	View/Edit Mouse

LCORL

Last updated October 19, 2025

Ligand dependent nuclear receptor corepressor like is a protein that in humans is encoded by the LCORL gene. ^[5]

Function

This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000178177 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015882 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Ligand dependent nuclear receptor corepressor like" . Retrieved 2016-11-11.

Kunieda T, Park JM, Takeuchi H, Kubo T (January 2003). "Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1)". FEBS Letters. 535 (1–3): 61–65. doi:10.1016/s0014-5793(02)03858-9. PMID 12560079. S2CID 83745027.
Sovio U, Bennett AJ, Millwood IY, Molitor J, O'Reilly PF, Timpson NJ, et al. (March 2009). "Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966". PLOS Genetics. 5 (3) e1000409. doi: 10.1371/journal.pgen.1000409 . PMC 2646138 . PMID 19266077.
Soranzo N, Rivadeneira F, Chinappen-Horsley U, Malkina I, Richards JB, Hammond N, et al. (April 2009). "Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size". PLOS Genetics. 5 (4) e1000445. doi: 10.1371/journal.pgen.1000445 . PMC 2661236 . PMID 19343178.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine. 16 (7–8): 247–253. doi:10.2119/molmed.2009.00159. PMC 2896464 . PMID 20379614.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000178177 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015882 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ligand dependent nuclear receptor corepressor like" . Retrieved 2016-11-11.

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LCORL

Contents

Function

References

Further reading