英文互译镜像站

Jeannie T. Lee

Last updated
Jeannie T. Lee
Alma materHarvard University, University of Pennsylvania Medical School, Massachusetts Institute of Technology
Awards2018 Harrington Rare Genetic Disease Scholar

2016 Lurie Award 2016 Centennial Award from Genetics Society of America 2015 Election to National Academy of Sciences (NAS) 2010 Molecular Biology Award from NAS 1999 Pew Scholar

1998 Basil O'Connor Scholar

Contents

Scientific career
Fieldsepigenetics, long noncoding RNA, X-inactivation, 3D genome, X-chromosome reactivation technology
Thesis  (1993)
Academic advisors Nancy Kleckner, Robert Nussbaum, Rudolf Jaenisch

Jeannie T. Lee is a Professor of Genetics (and Pathology) at Harvard Medical School and the Massachusetts General Hospital, and a Howard Hughes Medical Institute Investigator. She is known for her work on X-chromosome inactivation and for discovering the functions of a new class of epigenetic regulators known as long noncoding RNAs (lncRNAs), including Xist and Tsix.

Education

Jeannie T. Lee received an AB from Harvard College in Biochemistry & Molecular Biology and an MD/PhD in 1993 [1] from the University of Pennsylvania School of Medicine. [2] While at Harvard she worked with Nancy Kleckner on antisense regulation of Tn10 transposition. While at University of Pennsylvania School of Medicine her advisor was Robert L. Nussbaum. [3] Her PhD research focused on Fragile X syndrome, and led to her strong interest in X chromosome inactivation and epigenetics. [4] Then she did postdoctoral work with Rudolf Jaenisch at the Whitehead Institute, during which she discovered the nature of the X-inactivation center. [3] She was also Chief Resident of Laboratory Medicine at the Massachusetts General Hospital.

Research career

Lee joined the faculty at Harvard in 1997 and devoted her studies to noncoding RNA and sex chromosome dynamics during development and disease. Her major career research achievements include identifying the X inactivation center, [5] [6] discovering Tsix antisense RNA, [7] determining Xist's mechanism of action, [8] [9] demonstrating that a lncRNA is a regulator of Polycomb repressive complex 2, [8] [10] [11] [12] and determining that the X chromosome folds like origami and adopts a unique conformation.

Her studies established the existence and function of a group of lncRNAs. In a 2013 interview, she stated that this group of RNAs excited her because they control gene expression in a locus-specific way, by recruiting chromatin modifying activities to the locus, making the lncRNAs excellent drug design targets. She founded RaNA Therapeutics to test this idea. [3]

Upon conferring the Lurie Prize to Lee in 2016, Dr. Charles A. Sanders of the Foundation for the National Institutes of Health remarked: "Dr. Lee's work has revolutionized the field of epigenetics. Her research has led to groundbreaking contributions, and we now have a better understanding of the unique role that long non-coding RNAs play in gene expression, which could lead to the development of new therapeutics." [13]

Lee was President of the Genetics Society of America, [14] Codirector of the Harvard Epigenetics Initiative, and is Vice Chair of the Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School. She delivered a set of lectures to iBiology on X chromosome inactivation. [15]

Notable publications

Awards

References

  1. ↑ "Jeannie T. Lee". Massachusetts General Hospital. Archived from the original on August 15, 2018. Retrieved August 15, 2018.
  2. ↑ "Jeannie T. Lee".
  3. 1 2 3 "Interview with Jeannie T. Lee". Oligonucleotide Therapeutics Society. August 13, 2016. Archived from the original on August 2, 2018. Retrieved August 2, 2018.
  4. ↑ Viegas, J (2015). "QnAs with Jeannie T. Lee". Proc Natl Acad Sci U S A. 112 (48): 14745–6. Bibcode:2015PNAS..11214745V. doi: 10.1073/pnas.1521185112 . PMC   4672782 . PMID   26582793.
  5. ↑ Lee, J. T.; Strauss, W. M.; Dausman, J. A.; Jaenisch, R. (1996-07-12). "A 450 kb transgene displays properties of the mammalian X-inactivation center". Cell. 86 (1): 83–94. doi: 10.1016/s0092-8674(00)80079-3 . ISSN   0092-8674. PMID   8689690. S2CID   17888183.
  6. ↑ Lee, J. T.; Lu, N.; Han, Y. (1999-03-30). "Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain". Proceedings of the National Academy of Sciences of the United States of America. 96 (7): 3836–3841. Bibcode:1999PNAS...96.3836L. doi: 10.1073/pnas.96.7.3836 . ISSN   0027-8424. PMC   22381 . PMID   10097124.
  7. 1 2 Lee, J. T.; Davidow, L. S.; Warshawsky, D. (April 1999). "Tsix, a gene antisense to Xist at the X-inactivation centre". Nature Genetics. 21 (4): 400–404. doi:10.1038/7734. ISSN   1061-4036. PMID   10192391. S2CID   30636065.
  8. 1 2 3 Zhao, Jing; Sun, Bryan K.; Erwin, Jennifer A.; Song, Ji-Joon; Lee, Jeannie T. (2008-10-31). "Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome". Science. 322 (5902): 750–756. Bibcode:2008Sci...322..750Z. doi:10.1126/science.1163045. ISSN   1095-9203. PMC   2748911 . PMID   18974356.
  9. ↑ Minajigi, Anand; Froberg, John; Wei, Chunyao; Sunwoo, Hongjae; Kesner, Barry; Colognori, David; Lessing, Derek; Payer, Bernhard; Boukhali, Myriam (2015-07-17). "A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation". Science. 349 (6245) aab2276. doi:10.1126/science.aab2276. ISSN   0036-8075. PMC   4845908 . PMID   26089354.
  10. ↑ Zhao, Jing; Ohsumi, Toshiro K.; Kung, Johnny T.; Ogawa, Yuya; Grau, Daniel J.; Sarma, Kavitha; Song, Ji Joon; Kingston, Robert E.; Borowsky, Mark (2010-12-22). "Genome-wide identification of polycomb-associated RNAs by RIP-seq". Molecular Cell. 40 (6): 939–953. doi:10.1016/j.molcel.2010.12.011. ISSN   1097-4164. PMC   3021903 . PMID   21172659.
  11. ↑ Cifuentes-Rojas, Catherine; Hernandez, Alfredo J.; Sarma, Kavitha; Lee, Jeannie T. (2014-07-17). "Regulatory interactions between RNA and polycomb repressive complex 2". Molecular Cell. 55 (2): 171–185. doi:10.1016/j.molcel.2014.05.009. ISSN   1097-4164. PMC   4107928 . PMID   24882207.
  12. ↑ Zovoilis, Athanasios; Cifuentes-Rojas, Catherine; Chu, Hsueh-Ping; Hernandez, Alfredo J.; Lee, Jeannie T. (2016-12-15). "Destabilization of B2 RNA by EZH2 Activates the Stress Response". Cell. 167 (7): 1788–1802.e13. doi:10.1016/j.cell.2016.11.041. ISSN   1097-4172. PMC   5552366 . PMID   27984727.
  13. ↑ "Foundation for the NIH to Award Lurie Prize in Biomedical Sciences to Dr. Jeannie Lee for Pioneering Work in Epigenetics | FNIH". fnih.org. Archived from the original on 2017-09-30. Retrieved 2017-09-30.
  14. 1 2 "Jeannie T. Lee".
  15. ↑ "Jeannie Lee • iBiology". iBiology. Retrieved 2019-12-15.
  16. ↑ Kung, Johnny T. Y.; Colognori, David; Lee, Jeannie T. (March 2013). "Long noncoding RNAs: past, present, and future". Genetics. 193 (3): 651–669. doi:10.1534/genetics.112.146704. ISSN   1943-2631. PMC   3583990 . PMID   23463798.
  17. ↑ Lee, Jeannie T. (2012-12-14). "Epigenetic regulation by long noncoding RNAs". Science. 338 (6113): 1435–1439. Bibcode:2012Sci...338.1435L. doi:10.1126/science.1231776. ISSN   1095-9203. PMID   23239728. S2CID   206546141.
  18. ↑ Zhao, Jing; Ohsumi, Toshiro K.; Kung, Johnny T.; Ogawa, Yuya; Grau, Daniel J.; Sarma, Kavitha; Song, Ji Joon; Kingston, Robert E.; Borowsky, Mark; Lee, Jeannie T. (2010-12-22). "Genome-wide identification of polycomb-associated RNAs by RIP-seq". Molecular Cell. 40 (6): 939–953. doi:10.1016/j.molcel.2010.12.011. ISSN   1097-4164. PMC   3021903 . PMID   21172659.
  19. ↑ Jeon, Yesu; Lee, Jeannie T. (2011-07-08). "YY1 tethers Xist RNA to the inactive X nucleation center". Cell. 146 (1): 119–133. doi:10.1016/j.cell.2011.06.026. ISSN   1097-4172. PMC   3150513 . PMID   21729784.
  20. ↑ Xu, Na; Tsai, Chia-Lun; Lee, Jeannie T. (2006-02-24). "Transient homologous chromosome pairing marks the onset of X inactivation". Science. 311 (5764): 1149–1152. Bibcode:2006Sci...311.1149X. doi:10.1126/science.1122984. ISSN   1095-9203. PMID   16424298. S2CID   20362477.
  21. ↑ Lee, J. T.; Strauss, W. M.; Dausman, J. A.; Jaenisch, R. (1996-07-12). "A 450 kb transgene displays properties of the mammalian X-inactivation center". Cell. 86 (1): 83–94. doi: 10.1016/s0092-8674(00)80079-3 . ISSN   0092-8674. PMID   8689690. S2CID   17888183.
  22. ↑ "Interview with Jeannie T. Lee, MD, PHD". 6 August 2013. Archived from the original on 19 April 2017. Retrieved 18 April 2017.
  23. ↑ "Centennial Awards honor outstanding GENETICS articles". EurekAlert!. Retrieved 2017-09-30.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.
整站镜像下载 递归网站下载 霸屏SEO镜像站群 网站离线镜像 英文互译镜像站