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Isoquinoline 1-oxidoreductase

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isoquinoline 1-oxidoreductase
Identifiers
EC no. 1.3.99.16
CAS no. 155948-73-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, isoquinoline 1-oxidoreductase (EC 1.3.99.16) is an enzyme that catalyzes the chemical reaction

 
H2O
 
Isoquinoline 1-oxidoreductase
H2O
 
 
+ reduced acceptor
 

The three substrates of this enzyme are isoquinoline, an electron acceptor, and water. Its products are isocarbostyril and reduced acceptor. [1] [2] [3]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is isoquinoline:acceptor 1-oxidoreductase (hydroxylating).

References

  1. Enzyme 1.3.99.16 at KEGG Pathway Database.
  2. Lehmann M, Tshisuaka B, Fetzner S, Roger P, Lingens F (1994). "Purification and characterization of isoquinoline 1-oxidoreductase from Pseudomonas diminuta 7, a novel molybdenum-containing hydroxylase". J. Biol. Chem. 269 (15): 11254–60. doi: 10.1016/S0021-9258(19)78118-6 . PMID   8157655.
  3. Lehmann M, Tshisuaka B, Fetzner S, Lingens F (1995). "Molecular cloning of the isoquinoline 1-oxidoreductase genes from Pseudomonas diminuta 7, structural analysis of iorA and iorB, and sequence comparisons with other molybdenum-containing hydroxylases". J. Biol. Chem. 270 (24): 14420–9. doi: 10.1074/jbc.270.24.14420 . PMID   7782304.


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