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Glycine dehydrogenase (cyanide-forming)

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glycine dehydrogenase (cyanide-forming)
Identifiers
EC no. 1.4.99.5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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PMC articles
PubMed articles
NCBI proteins

In enzymology, glycine dehydrogenase (cyanide-forming) (EC 1.4.99.5) is an enzyme that catalyzes the chemical reaction

 
 
CO2
Glycine dehydrogenase (cyanide-forming)
 
CO2
 
+ 2 reduced acceptor
 

The two substrates of this enzyme are glycine and an electron acceptor. Its products are hydrogen cyanide, carbon dioxide, and reduced acceptor. [1] [2] [3] [4] [5]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with other acceptors. The systematic name of this enzyme class is glycine:acceptor oxidoreductase (hydrogen-cyanide-forming). Other names in common use include hydrogen cyanide synthase, and HCN synthase.

References

  1. Enzyme 1.4.99.5 at KEGG Pathway Database.
  2. Wissing F (1975). "Cyanide production from glycine by a homogenate from a Pseudomonas species". J. Bacteriol. 121 (2): 695–9. doi:10.1128/jb.121.2.695-699.1975. PMC   245984 . PMID   234422.
  3. Castric PA (1977). "Glycine metabolism by Pseudomonas aeruginosa: hydrogen cyanide biosynthesis". J. Bacteriol. 130 (2): 826–31. doi:10.1128/jb.130.2.826-831.1977. PMC   235287 . PMID   233722.
  4. Haas D; Blumer, C; Von Schroetter, C; Gaia, V; Défago, G; Keel, C; Haas, D (1998). "Characterization of the hcnABC gene cluster encoding hydrogen cyanide synthase and anaerobic regulation by ANR in the strictly aerobic biocontrol agent Pseudomonas fluorescens CHA0". J. Bacteriol. 180 (12): 3187–96. doi:10.1128/JB.180.12.3187-3196.1998. PMC   107821 . PMID   9620970.
  5. Blumer C, Haas D (2000). "Mechanism, regulation, and ecological role of bacterial cyanide biosynthesis". Arch. Microbiol. 173 (3): 170–7. Bibcode:2000ArMic.173..170B. doi:10.1007/s002039900127. PMID   10763748.


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