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ESHAP

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ESHAP is an acronym for relatively intensive chemotherapy regimen that is used for salvage therapy in relapsed or refractory lymphomas and Hodgkin lymphoma. In combination with monoclonal antibody Rituximab it is called R-ESHAP or ESHAP-R. [1]

R-ESHAP consists of:

  1. Rituximab, an anti-CD20-directed monoclonal antibody that kills both normal and malignant B-lymphocytes
  2. Etoposide, an epipodophyllotoxin topoisomerase inhibitor
  3. Solu-Medrol - Methylprednisolone, which is a glucocorticoid that can lyse lymphocytes
  4. High-dose Ara-C - cytarabine
  5. Platinol - Cisplatin, a platinum-based antineoplastic agent, also an alkylating antineoplastic agent.

Dosing regimen

DrugDoseModeDays
Rituximab 375 mg/m2IV infusionDay 0
Etoposide 40 mg/m2IV infusion over 1 hrDays 1-4
Solu-Medrol - Methylprednisolone 500 mgIV bolus over 15 minDays 1-5
High-dose Ara-C — cytarabine 2000 mg/m2IV infusion over 2 hrsDay 5
Platinol (cisplatin) 25 mg/m2IV continuous infusion over 24 hrsDays 1-4

References

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