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Drug vectorization

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In pharmacology and medicine, vectorization of drugs refers to (intracellular) targeting with plastic, noble metal or silicon nanoparticles or liposomes to which pharmacologically active substances are reversibly bound or attached by adsorption. [1] [2]

CNRS researchers have devised a way to overcome the problem of multidrug resistance using polyalkyl cyanoacrylate (PACA) nanoparticles as "vectors". [3]

As a developing concept, drug nanocarriers are expected to play a major role in delivering multiple drugs to tumor tissues by overcoming semi-permeable membranes and biological barriers such as the blood–brain barrier. [4]

References

  1. ↑ Couvreur P. (2001). "Drug vectorization or how to modulate tissular and cellular distribution of biologically active compounds". Ann Pharm Fr. 59 (4): 232–8. PMID   11468577.
  2. ↑ Secret, Emilie; Smith, Kevin; Dubljevic, Valentina; Moore, Eli; Macardle, Peter; et al. (2012-11-30). "Antibody-Functionalized Porous Silicon Nanoparticles for Vectorization of Hydrophobic Drugs" . Advanced Healthcare Materials. 2 (5). Wiley: 718–727. doi:10.1002/adhm.201200335. ISSN   2192-2640. PMID   23203914. S2CID   879226.
  3. ↑ "CNRSinfo - en380a6". Archived from the original on 2015-07-19. Retrieved 2016-01-28.
  4. ↑ Su, Chia-Wei; Chiang, Chih-Sheng; Li, Wei-Ming; Hu, Shang-Hsiu; Chen, San-Yuan (2014). "Multifunctional nanocarriers for simultaneous encapsulation of hydrophobic and hydrophilic drugs in cancer treatment". Nanomedicine (Lond.). 9 (10): 1499–515. doi:10.2217/nnm.14.97. PMID   25253498.

See also


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