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Dihydroorotate dehydrogenase (fumarate)

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Dihydroorotate dehydrogenase (fumarate)
Identifiers
EC no. 1.3.98.1
CAS no. 2603876
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Dihydroorotate dehydrogenase (fumarate) (EC 1.3.98.1, dihydroorotate oxidase, pyr4 (gene)) is an enzyme with systematic name (S)-dihydroorotate:fumarate oxidoreductase. [1] [2]

The enzyme is found in the bacterium Lactococcus lactis and the yeast Saccharomyces cerevisiae . [3] [4] [5] [6] It contains the cofactor, flavin mononucleotide and catalyses the following chemical reaction which is part of the biosynthesis of pyrimidine nucleotides. [7]

L-hydroorotic acid.svg
dihydroorotic acid
+
 
Fumarsaure.svg
fumaric acid
 
 
 
Dihydroorotate dehydrogenase (fumarate)
 
 
 
Orotic acid.svg
orotic acid
+
 
Kwas bursztynowy007.svg
succinic acid

References

  1. ↑ Inaoka DK, Sakamoto K, Shimizu H, Shiba T, Kurisu G, Nara T, Aoki T, Kita K, Harada S (October 2008). "Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction". Biochemistry. 47 (41): 10881–91. doi:10.1021/bi800413r. PMID   18808149.
  2. ↑ Cheleski J, Wiggers HJ, Citadini AP, da Costa Filho AJ, Nonato MC, Montanari CA (April 2010). "Kinetic mechanism and catalysis of Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry". Analytical Biochemistry. 399 (1): 13–22. doi:10.1016/j.ab.2009.11.018. PMID   19932077.
  3. ↑ Björnberg O, Rowland P, Larsen S, Jensen KF (December 1997). "Active site of dihydroorotate dehydrogenase A from Lactococcus lactis investigated by chemical modification and mutagenesis". Biochemistry. 36 (51): 16197–205. doi:10.1021/bi971628y. PMID   9405053.
  4. ↑ Rowland P, Björnberg O, Nielsen FS, Jensen KF, Larsen S (June 1998). "The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function". Protein Science. 7 (6): 1269–79. doi:10.1002/pro.5560070601. PMC   2144028 . PMID   9655329.
  5. ↑ Nørager S, Arent S, Björnberg O, Ottosen M, Lo Leggio L, Jensen KF, Larsen S (August 2003). "Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function". The Journal of Biological Chemistry. 278 (31): 28812–22. doi: 10.1074/jbc.M303767200 . PMID   12732650.
  6. ↑ Zameitat E, Pierik AJ, Zocher K, Löffler M (September 2007). "Dihydroorotate dehydrogenase from Saccharomyces cerevisiae: spectroscopic investigations with the recombinant enzyme throw light on catalytic properties and metabolism of fumarate analogues". FEMS Yeast Research. 7 (6): 897–904. doi: 10.1111/j.1567-1364.2007.00275.x . PMID   17617217.
  7. ↑ Enzyme 1.3.98.1 at KEGG Pathway Database.


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