Di Francesco (or di Francesco) is an Italian surname. Notable people with this surname include:

• Dario DiFrancesco (born 1948), Italian physiologist
• David DiFrancesco (born 1949), American photo scientist, inventor, cinematographer and photographer
• Donald DiFrancesco (born 1944), American politician
• Eusebio Di Francesco (born 1969), Italian football player and manager
• Federico Di Francesco (born 1994), Italian footballer
• Gianmarco Di Francesco (born 1989), Italian cyclist
• Giovanni di Francesco (1412–1459), Italian painter
• Lupo di Francesco (fl. 14th century), Italian sculptor and architect
• Mauro Di Francesco (1951–2025), Italian actor, comedian and television personality
• Philippe Di Francesco, French-American mathematician
• Stefano di Francesco (died 1427), Italian painter

See also

• Francesco
• De Francesco

Surname list

This page lists people with the surname Di Francesco.
If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link.