De Francesco (or de Francesco) is an Italian surname. Notable people with this surname include:

• Alberto De Francesco (born 1994), Italian football player
• Devlin DeFrancesco (born 2000), Canadian-Italian auto racing driver
• Francesco De Francesco (born 1977), Italian football striker
• Grete De Francesco (1893–1945), German-speaking writer
• Joey DeFrancesco (1971–2022), American jazz organist, trumpeter, saxophonist, and occasional singer
• John DeFrancesco (1940–2024), American jazz organist and vocalist
• Johnny DeFrancesco (born 1965), merican blues guitarist
• Lucas de Francesco (born 1981), Italian football striker
• Matteuccia de Francesco (died 1428), an alleged Italian witch and nun
• Roberto De Francesco (born 1964), Italian actor
• Sebastian DeFrancesco (1953–2023), American paralympic athlete and table tennis player
• Tony DeFrancesco (born 1963), American baseball coach

See also

• Francesco
• Di Francesco

Surname list

This page lists people with the surname De Francesco.
If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link.