DeStefano is an Italian surname with Greek origin. Notable people with the surname include:

• Anthony DeStefano (born 1965), American author
• Chris DeStefano, American singer
• Dusty DeStefano (1917–1982), American basketball and baseball coach
• Frank DeStefano, medical researcher
• Fred DeStefano (1900–1974), American football player
• Joe DeStefano (born 1960), politician
• John M. DeStefano (died 2008), American artist
• John DeStefano Jr. (born 1955), American mayor
• Johnny DeStefano (born 1979), American political advisor
• Lauren DeStefano (born 1984), American author
• Mario Anthony DeStefano (1915–1975), American gangster
• Mike DeStefano (born 1966), American comedian
• Robert DeStefano (born 1962), American chiropractor
• Sam DeStefano (1909-1973), American mobster
• Stephen DeStefano (born 1966), American comics artist

See also

• Ricci v. DeStefano

Surname list

This page lists people with the surname DeStefano.
If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link.