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Artemisinic aldehyde Delta11(13)-reductase

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Artemisinic aldehyde Delta11(13)-reductase
Identifiers
EC no. 1.3.1.92
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
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PMC articles
PubMed articles
NCBI proteins

Artemisinic aldehyde Delta11(13)-reductase (EC 1.3.1.92, Dbr2) is an enzyme with systematic name artemisinic aldehyde:NADP+ oxidoreductase. This enzyme catalyses the following chemical reaction

 
 
H+
 
Artemisinic aldehyde Delta11(13)-reductase
H+
 
 
 

The three substrates of this enzyme are artemisinic aldehyde, reduced nicotinamide adenine dinucleotide phosphate (NADPH), and a proton. Its products are (11R)-dihydroartemisinic aldehyde and oxidised NADP+. [1] This enzyme is present in Artemisia annua . [2] [3]

References

  1. Enzyme 1.3.1.92 at KEGG Pathway Database.
  2. Bertea CM, Freije JR, van der Woude H, Verstappen FW, Perk L, Marquez V, De Kraker JW, Posthumus MA, Jansen BJ, de Groot A, Franssen MC, Bouwmeester HJ (January 2005). "Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua". Planta Medica. 71 (1): 40–7. Bibcode:2005PlMed..71...40B. doi: 10.1055/s-2005-837749 . PMID   15678372.
  3. Zhang Y, Teoh KH, Reed DW, Maes L, Goossens A, Olson DJ, Ross AR, Covello PS (August 2008). "The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua". The Journal of Biological Chemistry. 283 (31): 21501–8. doi: 10.1074/jbc.M803090200 . PMID   18495659.
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