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Aminopyrimidine aminohydrolase

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Aminopyrimidine aminohydrolase
Identifiers
EC no. 3.5.99.2
CAS no. 9024-80-0
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Aminopyrimidine aminohydrolase (EC 3.5.99.2, thiaminase, thiaminase II, tenA (gene)) is an enzyme with systematic name 4-amino-5-aminomethyl-2-methylpyrimidine aminohydrolase. [1] [2] [3] [4] [5] [6] [7] This enzyme catalyses the following chemical reaction

(1) 4-amino-5-aminomethyl-2-methylpyrimidine + H2O 4-amino-5-hydroxymethyl-2-methylpyrimidine + ammonia
(2) thiamine + H2O 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole

This enzyme was previously known as thiaminase II.

References

  1. ↑ Fujita A, Nose Y (July 1954). "The second type of bacterial thiaminase". The Journal of Vitaminology. 1 (1): 1–7. doi: 10.5925/jnsv1954.1.1 . PMID   13243520.
  2. ↑ Ikehata H (1960). "Purification of thiaminase II". J. Gen. Appl. Microbiol. 6: 30–39. doi: 10.2323/jgam.6.30 .
  3. ↑ Toms AV, Haas AL, Park JH, Begley TP, Ealick SE (February 2005). "Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II". Biochemistry. 44 (7): 2319–29. doi:10.1021/bi0478648. PMID   15709744.
  4. ↑ Benach J, Edstrom WC, Lee I, Das K, Cooper B, Xiao R, Liu J, Rost B, Acton TB, Montelione GT, Hunt JF (May 2005). "The 2.35 A structure of the TenA homolog from Pyrococcus furiosus supports an enzymatic function in thiamine metabolism" . Acta Crystallographica Section D. 61 (Pt 5): 589–98. doi:10.1107/S0907444905005147. PMID   15858269.
  5. ↑ Jenkins AH, Schyns G, Potot S, Sun G, Begley TP (August 2007). "A new thiamin salvage pathway". Nature Chemical Biology. 3 (8): 492–7. doi:10.1038/nchembio.2007.13. PMID   17618314.
  6. ↑ Jenkins AL, Zhang Y, Ealick SE, Begley TP (February 2008). "Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis". Bioorganic Chemistry. 36 (1): 29–32. doi:10.1016/j.bioorg.2007.10.005. PMC   2293645 . PMID   18054064.
  7. ↑ French JB, Begley TP, Ealick SE (September 2011). "Structure of trifunctional THI20 from yeast". Acta Crystallographica Section D. 67 (Pt 9): 784–91. doi:10.1107/S0907444911024814. PMC   3169313 . PMID   21904031.
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