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Acetoacetyl-CoA synthase

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Acetoacetyl-CoA synthase
Identifiers
EC no. 2.3.1.194
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
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PMC articles
PubMed articles
NCBI proteins

Acetoacetyl-CoA synthase (EC 2.3.1.194, NphT7) is an enzyme with systematic name acetyl-CoA:malonyl-CoA C-acetyltransferase (decarboxylating). [1] This enzyme catalyses the following chemical reaction

acetyl-CoA + malonyl-CoA acetoacetyl-CoA + CoA + CO2

The enzyme from the soil bacterium Streptomyces sp. CL190 produces acetoacetyl-CoA.

References

  1. Okamura E, Tomita T, Sawa R, Nishiyama M, Kuzuyama T (June 2010). "Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway". Proceedings of the National Academy of Sciences of the United States of America. 107 (25): 11265–70. Bibcode:2010PNAS..10711265O. doi: 10.1073/pnas.1000532107 . PMC   2895072 . PMID   20534558.
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