WIRO may refer to:

• Wyoming Infrared Observatory
• WIRO (FM), a radio station (106.7 FM) licensed to serve Ironton, Ohio, United States
• WKSG (FM), a radio station (98.3 FM) licensed to serve Garrison, Kentucky, United States, which held the call sign WIRO in 2022
• WITO, a radio station (1230 AM) licensed to serve Ironton, Ohio, which held the call sign WIRO from 1951 to 2022
• Wirö language, an Indigenous language of Venezuela and eastern Colombia

This disambiguation page lists articles associated with the title WIRO.
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