Up in Smoke is a 1978 film featuring Cheech and Chong.

Up in Smoke may also refer to:

• Up in Smoke (album), the soundtrack to the 1978 film, or the title track also covered by Hank Williams III
• Up in Smoke (album), a 1995 album by Indo G and Lil' Blunt
• Up in Smoke (1957 film), starring the comedy team of The Bowery Boys
• "Up in Smoke" (CSI: Crime Scene Investigation), a sixth-season episode of CSI: Crime Scene Investigation
• "Up in Smoke" (NCIS), a ninth-season episode of NCIS
• Up in Smoke Tour, a West Coast hip hop tour which took place in 2000
• Up in Smoke, an alternate name used by the professional wrestling tag team Cheech and Cloudy
• "Up in Smoke", a song by Hollywood Undead from Notes from the Underground
• "Up in Smoke", a song by Lower Than Atlantis from World Record
• "Up in Smoke", a song by Neck Deep from A History of Bad Decisions

This disambiguation page lists articles associated with the title Up in Smoke.
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