Sysonby may refer to:

• Sysonby (horse) (1902–1906), an American Thoroughbred racehorse
• Sysonby, Leicestershire, England
• Sysonby Handicap, a horse race named after the horse
• Baron Sysonby, a title in the Peerage of the United Kingdom
• Victoria Ponsonby, Baroness Sysonby (1874 – 1955), a British cookbook author

This disambiguation page lists articles associated with the title Sysonby.
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