Spence is a surname. Notable people with the surname include:

• Anne Spence, American aerospace engineer
• Ara Spence (1793–1866), American jurist from Maryland
• Basil Spence (1907–1976), British architect
• Brent Spence (1874–1967), American politician, attorney, and banker
• Bruce Spence (born 1945), New Zealand-born Australian actor
• Catherine Helen Spence (1825–1910), Australian reformer and suffragist
• Charles Spence, experimental psychologist
• Craig J. Spence (1940–1989), American journalist, lobbyist, and socialite
• Derek Spence (born 1952), Irish footballer
• Djed Spence (born 2000), English footballer
• E. Lee Spence, American author, editor, adventurer and underwater archaeologist
• Errol Spence Jr., American boxer
• Fiona Spence, British-Australian actress
• Floyd Spence, American politician
• George Spence (Canadian politician) (1880–1975), Canadian politician
• George Spence (MP) (1787–1850), British politician
• George Spence (footballer, born 1877) (1877–?), Scottish footballer
• George Spence (footballer, born 1904) (1904–?), English footballer
• Gerry Spence (1929–2025), American trial lawyer
• Jack Spence (disambiguation), several people
• James Spence (surgeon), Scottish Surgeon
• Joe Spence (footballer born 1898), English footballer for Manchester United in the 1920s
• Joe Spence (footballer born 1925), English footballer for York City in the 1950s
• John Brodie Spence, South Australian banker and politician, brother of Catherine
• John S. Spence, American politician from Maryland
• John Selby Spence (Catholic bishop), American Catholic bishop
• John Spence (politician), British politician
• John Spence (musician), founding member of the band No Doubt
• Jonathan Spence, English historian
• Jordan Spence (born 1990), English footballer
• Jordan Spence (ice hockey) (born 2001), Japanese Canadian
• Joseph Spence (author), English anecdotist
• Joseph Spence (musician), Bahamian guitarist and blues musician
• Joy Spence (born 1951), Jamaican master blender
• Julian Spence (1929–1990), American football player
• Kenneth Spence, prominent American psychologist
• Lansford Spence, Jamaican sprinter
• Lewis Spence, journalist and writer
• Linda Spence, Irish-Scottish cricketer
• Louie Spence, British dancer
• Malcolm Spence (ice hockey) (born 2006), Canadian ice hockey player
• Michael Spence, American economist
• Nicky Spence, Scottish opera singer
• Noah Spence, American football player
• Phil Spence, American basketball player and coach
• Robert Spence (chemist) (1905–1976), British nuclear chemist
• Russell Spence, English race car driver
• Sam Spence (1927–2016), American composer and musician
• Shaun Spence (born 1991), Australian rugby player
• Sion Spence (born 2000), Welsh footballer
• Skip Spence (1946–1999), American rock musician
• Steve Spence, American long-distance runner
• Thomas Spence (1750–1814), English Radical democrat
• Toby Spence (born 1969), English tenor
• Vivienne Spence, Jamaican track and field athlete
• William Spence (1846–1926), Australian trade unionist and politician
• William Wallace Spence (1815–1915), American financier
• Willie Spence (1999–2022), American singer
• Wishart Spence, Canadian jurist

Surname list

This page lists people with the surname Spence.
If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link.