Samuel Henderson may refer to:

• Samuel Henderson (Pennsylvania politician) (1764–1841), member of the U.S. House of Representatives from Pennsylvania
• Samuel Henderson (Indianapolis mayor) (c. 1800–1883), first mayor of Indianapolis, Indiana
• Samuel Henderson (born 1827) (c. 1827–1907), African-American groundskeeper and Catholic convert, under consideration for beatification
• Sam Henderson (footballer), English footballer

See also

• Sam Henderson (born 1969), American cartoonist, writer, and expert on American comedy history

Topics referred to by the same term

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