Fictional characters

• Ruby Allen, EastEnders character played by Louisa Lytton
• Ruby Buckton, Home and Away character played by Rebecca Breeds
• Ruby Crescent, an O-Parts Hunter character
• Ruby Dennis, the protagonist of the film Dear Mr. Wonderful
• Ruby Gillman, the main character of 2023 animated fantasy film Ruby Gillman
• Ruby Hale, a recurring character in MARVEL's Agents of S.H.I.E.L.D. played by Dove Cameron
• Ruby Heart, protagonist of Marvel vs. Capcom 2
• Ruby Hoshino, Oshi no Ko; see List of Oshi no Ko characters
• Ruby Kurosawa, a fictional character from the mixed-media project Love Live! Sunshine!!
• Ruby Moon, a character from Cardcaptor Sakura manga and anime
• Ruby Ramirez, a character from Treehouse's Rusty Rivets
• Ruby Marshall, a character from the preschool TV series Dot.
• Ruby Rhod, a character (played by Tucker) in the late 1990s film The Fifth Element
• Ruby Rose (RWBY character), the protagonist of the animated webseries RWBY
• Ruby Thewes, a character in the novel Cold Mountain by Charles Frazier and in the film
• Ruby Trollman, a Trollz character
• Ruby, one of the identical twins in the Jacqueline Wilson novel Double Act
• Ruby (Jewelpet)
• Ruby (Pokémon)
• Ruby (Once Upon a Time) (better known as Red Riding Hood), a character from the ABC television drama Once Upon a Time
• Ruby (Steven Universe)
• Ruby (Supernatural)
• Ruby, an According to Jim character
• Ruby, a promotional character created by ATI Technologies
• Ruby, an anthro rabbit in the Max & Ruby book and television series
• Ruby, the protagonist of the radio drama Ruby the Galactic Gumshoe
• Ruby, the protagonist of the Canadian TV series Ruby Gloom
• Ruby, a potato in the British animated series Small Potatoes
• Ruby, an anthro mouse in the British children's series Big & Small
• Ruby, a character portrayed by Amrita Singh in the 1985 Indian film Mard
• Ruby, a character portrayed by Kareena Kapoor in the 2012 Indian film Agent Vinod
• Ruby, a character in The Land Before Time

Films

• Ruby (1977 film), a supernatural horror
• Ruby (1992 film), about Jack Ruby

Games

• Pokémon Ruby , released in 2002 for Japan and 2003 internationally
• Pokémon Omega Ruby , a remake of Pokémon Ruby

Television

• Ruby (talk show), a British late night talk show
• Ruby (2008 TV series), a Style Network program
• Ruby (2012 TV series), an Arab dramatic series
• Ruby Gallagher, a character of the ABC Family TV series Ruby & The Rockits
• The Ruby, the diner in Canadian series Corner Gas , as well as the film and animated versions

Literature

• Ruby (novel), a 1994 novel by V. C. Andrews

Music