The Women's quadruple sculls event at the 2010 South American Games was held over March 21 at 10:40.
| World Best Time | ||||
|---|---|---|---|---|
| World best time |  Germany | 6:10.80 | Duisburg, Germany | 1996 |
| Rank | Rowers | Country | Time |
|---|---|---|---|
 | Laura Abalo, Lucia Palermo, Clara Rohner, Anabela Torres |  Argentina | 7:20.73 |
 | Fabiana Beltrame, Camila Carvalho, Kissya Costa, Carolina Rocha |  Brazil | 7:25.48 |
 | Daniela Johana Hernandez, Soraya Arriaza, Florencia Piederit, Pamela Olave |  Chile | 7:41.86 |
| 4 | Roxiery Guerra, Joselin Izaze, Kimberlin Meneses, Yolennis Majanao |  Venezuela | 7:52.64 |