Route 22 is a common name for roads and highways in many countries.

Route 22 may also refer to:

• Route 22 (MTA Maryland), a bus route in Baltimore, Maryland, U.S.
• Route 22 (MBTA), a bus route in Boston, US
• London Buses route 22, a bus route in London, UK
• 22 Fillmore, a bus route in San Francisco

This disambiguation page lists articles associated with the title Route 22.
If an internal link led you here, you may wish to change the link to point directly to the intended article.