O Brother, Where Art Thou? or variants may refer to:
- O Brother, Where Art Thou? , 2000 film written, produced, co-edited and directed by Joel and Ethan Coen
- O Brother, Where Art Thou? (soundtrack), soundtrack of the film
- "Oh Brother, Where Art Thou?", 1991 episode of the television series The Simpsons
- "O Brother, Where Bart Thou?", 2009 episode of the television series The Simpsons
- "O Brother, Where Art Thou?" (Supergirl), episode of the television series Supergirl
- O Brother Where Art Thou? (Supernatural), an episode of the television series Supernatural
This disambiguation page lists articles associated with the title O Brother, Where Art Thou?.
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