Look up mainframe in Wiktionary, the free dictionary.

A mainframe computer is a type of large data processing system.

Mainframe may also refer to:

• Mainframe Studios, a Canadian computer animation company founded as Mainframe Entertainment

Fictional entities

• Mainframe (comics), several Marvel Comics characters
• Mainframe (G.I. Joe), a character in the G.I. Joe universe
• Mainframe, a character from the game Gunman Chronicles
• Mainframe, the city in the animated series ReBoot
• Tina "Mainframe" Cassidy, a character from the animated TV series COPS
• Mainframe, a character in Gene Wolfe's series of novels The Book of the Long Sun

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