Television

• Lost (TV series), a 2004 American drama series about people who become stranded on a mysterious island
• Lost (2001 TV series), a short-lived American and British reality series
• Lost (South Korean TV series), a 2021 South Korean series
• "Lost" (The Bill), a 1985 episode
• "Lost" (Shameless), an episode of the American TV series Shameless
• "Lost" (Stargate Universe), an episode of science fiction series Stargate Universe
• "Lost", an episode of Unleashed!
• "Lost", an episode of the Canadian documentary TV series Mayday
• "Lost", an episode of Disney's So Weird
• "The Lost" (Class), an episode of the first series of the Doctor Who spin-off series Class

Films

• Lost (1950 film), a Mexican film directed by Fernando A. Rivero
• Lost (1956 film), a British thriller starring David Farrar
• Lost (1983 film), an American film directed by Al Adamson
• Lost! (film), a 1986 Canadian film directed by Peter Rowe
• Lost (2004 film), an American thriller starring Dean Cain
• The Lost (2006 film), an American psychological horror starring Marc Senter
• Lost (2023 film), an Indian Hindi-language thriller film

Literature

• Lost (Maguire novel), a 2001 horror/mystery novel by Gregory Maguire
• Lost (Robotham novel), a 2005 Michael Robotham novel
• Lost, a novel by Alice Lichtenstein
• Lost: A Memoir , a 2009 memoir by Canadian author Cathy Ostlere
• The Lost: A Search for Six of Six Million, a 2006 memoir by Daniel Mendelsohn
• The Lost (Durst novel), a 2014 fantasy novel by American author Sarah Beth Durst

Music

Video games

• Lost: Via Domus , a 2008 video game by Ubisoft based on the Lost TV series
• The Lost (video game), a 2002 vaporware game by Irrational Games