Arts

• Kirk Covington, American musician

• Kirk Docker, co-creator of Australian TV series You Can't Ask That
• Kirk Franklin (1970– ), American gospel musician
• Kirk Hammett (1962– ), American musician, lead guitarist of Metallica
• Kirk Jarvinen (1967–), American artist
• Kirk Joseph (1961–), American musician
• Kirk Kelly (c. 1960–), American singer
• Kirk Lightsey (1937–), American pianist
• Kirk Mitchell (1950–), American author
• Kirk Pengilly (1958– ), Australian musician
• Kirk Powers (1957– ), American musician
• Kirk Whalum (1958– ), American saxophonist
• Kirk Windstein (1965– ), American musician

Athletics

• Kirk Baptiste (1963– ), American Olympics athlete
• Kirk Barton (1984– ), American football player
• Kirk Baumgartner (1967– ), American football player
• Kirk Bowman (1952– ), Canadian ice hockey player
• Kirk Broadfoot (1984– ), Scottish footballer
• Kirk Bullinger (1969– ), American baseball player
• Kirk Chambers (1979– ), American football player
• Kirk Cousins (1988– ), American football player
• Kirk Dixon (1984– ), English rugby player
• Kirk Dressendorfer (1969– ), American baseball player
• Kirk Earlywine (1964– ), American basketball coach
• Kirk Edwards (1984– ), Barbadian cricketer
• Kirk Ferentz (1955– ), American football coach
• Kirk Furey (1976– ), Canadian ice hockey player
• Kirk Gibson (1957– ), American baseball player
• Kirk Hanefeld (1956– ), American golfer
• Kirk Haston (1979– ), American basketball player
• Kirk Herbstreit (1969– ), American sportscaster
• Kirk Hilton (1981– ), English footballer
• Kirk Hinrich (1981– ), American basketball player
• Kirk Hudson (1986– ), English footballer
• Kirk Hunter (1963– ), Northern Irish footballer
• Kirk Jackson (1976– ), English footballer
• Kirk Johnson (1972– ), Canadian boxer
• Kirk Lowdermilk (1963– ), American football player
• Kirk Maltby (1972– ), Canadian ice hockey player
• Kirk McCarthy (1966–2004), Australian motorcycle racer
• Kirk McCaskill (1961– ), Canadian baseball player
• Kirk McLean (1966– ), Canadian ice hockey player
• Kirk Merritt (born 1997), American football player
• Kirk Morrison (1972– ), American football player
• Kirk Morrison (poker player), American poker player
• Kirk Muller (1966– ), Canadian ice hockey player
• Kirk Netherton (1985– ), English rugby player
• Kirk Nielsen (1973– ), American ice hockey player
• Kirk O'Bee (1977– ), American cyclist
• Kirk Olivadotti (1974– ), American football coach
• Kirk Palmer (1986– ), Australian Olympics swimmer
• Kirk Penney (1980– ), New Zealand basketball player
• Kirk Powell (1972– ), Jamaican cricketer
• Kirk Radomski (1969– ), American figure in the baseball steroids scandal
• Kirk Reynoldson (1979– ), Australian rugby player
• Kirk Rueter (1970– ), American baseball player
• Kirk Saarloos (1979– ), American baseball player
• Kirk Scrafford (1967– ), American football player
• Kirk Shelmerdine (1958– ), American race car driver
• Kirk Yeaman (1983– ), English rugby player

Entertainment

• Kirk Acevedo (1974– ), American actor
• Kirk Alyn (1910–1999), American actor
• Kirk Baily (1963–2022), American actor
• Kirk Baltz (1959– ), American actor
• Kirk Baxter (1972– ), Australian film editor
• Kirk Brandon (1956– ), English musician
• Kirk Browning (1921–2008), American television executive
• Kirk Cameron (1970– ), American actor
• Kirk DeMicco (1969– ), American screenwriter
• Kirk Degiorgio, British DJ
• Kirk Demorest, American filmmaker
• Kirk Douglas (1916–2020), American actor
• Kirk Fogg (1959– ), American actor
• Kirk Francis (1947– ), American film sound mixer
• Kirk Harris, American actor
• Kirk Thornton (1956– ), American voice actor
• Kirk B. R. Woller (1962– ), American actor

Finance

• Kirk Boott (1791–1837), American industrialist
• Kirk Kerkorian (1917–2015), American businessman

Law

• Kirk Anderson (judge) (fl. 2000s), Jamaican judge
• Kirk Bloodsworth (1960– ), American advocate for justice reform
• Kirk Cashmere (1955–2004), American lawyer

Military

• Kirk Lippold, American naval officer

Politics

• Kirk Cornish, Bahamian politician
• Kirk Cox (1957– ), American politician
• Kirk Dawes (1958– ), British mediator
• Kirk Fordham (1967– ), American Congressional aide
• Kirk Fordice (1934–2004), American politician, governor of Mississippi
• Kirk Humphreys (1950– ), American politician
• Kirk MacDonald, Canadian politician
• Kirk Schuring (1952– ), American politician
• Kirk Talbot (1969– ), Louisiana politician

Science

• Kirk Bryan (geologist) (1888–1950), American geologist
• Kirk Bryan (oceanographer) (1929– ), American oceanographer

Others

• Kirk Hyslop (1889–?), Canadian architect
• Kirk Lankford (1985– ), American murderer
• Kirk Martinez, English academic
• Kirk Schulz, president of Kansas State University
• Kirk White, Pagan lecturer and author