The U.S. Army Combined Arms Support Command (CASCOM), a major subordinate command of the Training and Doctrine Command (TRADOC), is located at Fort Lee, Virginia. Under the CASCOM command is the Sustainment Center of Excellence (SCoE).

Lieutenant General Joseph Richard Inge is a retired officer of the United States Army. He served as Deputy Commander, United States Northern Command, and Vice Commander, United States Element, North American Aerospace Defense Command, headquartered at Peterson Air Force Base, Colorado in 2007. He retired in 2007, after a 38-year career.

Brigadier General Jesse R. Cross, USA was the 50th Quartermaster General of the United States Army and the Commanding General of the U.S. Army Quartermaster School at Fort Lee, Virginia.

General William Gilbert Townsend Tuttle Jr. was a United States Army four-star general who served as Commanding General, United States Army Materiel Command from 1989 to 1992.

Lieutenant General Kathleen M. Gainey is a retired United States Army general who served as Deputy Commander, United States Transportation Command at Scott Air Force Base, Illinois. She retired in 2013.

Billy King Solomon is a retired Quartermaster officer, U.S. Army Lieutenant General and former Commander of the Combined Arms Support Command, Fort Lee, Virginia.

Stephen R. Lyons is a retired four-star general in the United States Army who last served as the 13th commander of the United States Transportation Command from August 2018 to October 2021. He previously served as the commanding general of United States Army Combined Arms Support Command/Sustainment Center of Excellence as well as the senior mission commander for Fort Lee, Virginia, from 2014 to 2015.

Rodney D. Fogg is a retired United States Army major general who last served as the Deputy Chief of Staff for Logistics and Operations of the United States Army Materiel Command from August 2021 to August 2022. He also served as the Commanding General of the United States Army Combined Arms Support Command and Sustainment Center of Excellence at Fort Lee, Virginia from September 2018 to July 2021.

David Wilson is a United States Army major general who serves as the Commanding General of the United States Army Sustainment Command since July 19, 2022. He most recently served as the Commanding General of 8th Theater Sustainment Command at Fort Shafter, Hawaii from June 16, 2020, to June 14, 2022. He previously served as the Director J/U-4, United States Forces Korea/United Nations Command/Deputy Director, C4 Combined Forces Command located in Camp Humphreys, Republic of Korea and as the 40th Chief of Ordnance and Commandant of the United States Army Ordnance School at Fort Lee, Virginia.

Brigadier General John F. "Jack" Haley is a retired general officer in the United States Army and served as the 38th Chief of Ordnance and Commandant of the U.S. Army Ordnance School at Fort Lee, Virginia.

Edward Michael Daly is a four-star general in the United States Army who serves as the 20th commanding general of the U.S. Army Materiel Command. He previously served as the deputy commanding general of Army Materiel Command from August 7, 2017 to July 2, 2020. In his role, he is responsible for managing the day-to-day operations of the army's logistics enterprise. He also served as the Senior Commander of Redstone Arsenal, Redstone. He assumed his current assignment on July 2, 2020.

Major General Clark W. LeMasters Jr. is a serving general officer in the United States Army and serves as the 35th Commanding General of the U.S. Army Tank-automotive and Armaments Command Life Cycle Management Command. Previously, he served as the 36th Chief of Ordnance for the U.S. Army and Commandant of the United States Army Ordnance School at Fort Lee, Virginia.

Major General William Estel Potts was a career officer in the United States Army and served as the 22nd Chief of Ordnance for the United States Army Ordnance Corps.

Major General Lynn A. Collyar is a retired general officer in the United States Army and served as the Commanding General, U.S. Army Aviation & Missile Command between from 2012 to 2014. Prior to this assignment, he served as the 35th Chief of Ordnance and Commandant of the U.S. Army Ordnance School at Aberdeen Proving Ground, Maryland and Fort Lee, Virginia.

Vincent E. Boles is a retired major general in the United States Army and served as the 33rd Chief of Ordnance and Commandant of the U.S. Army Ordnance School at Aberdeen Proving Grounds, Maryland.

Major General Dennis K. Jackson is a retired general officer in the United States Army and served as the director for logistics, J-4, United States Central Command, MacDill Air Force Base, Florida. Prior to this assignment, he served as the 30th Chief of Ordnance and Commandant of the U.S. Army Ordnance School at Aberdeen Proving Grounds, Maryland.

Major General James W. Monroe is a retired general officer in the United States Army and served as the Commanding General of the United States Army Industrial Operations Command at Rock Island Arsenal, Illinois from 1995 to 1998. Prior to this, he served as the 28th Chief of Ordnance and Commandant of the U.S. Army Ordnance School at Aberdeen Proving Grounds, Maryland.

Major General Robert David Shadley is a retired general officer in the United States Army and served as the Director of Logistics, G-4, for the United States Army Forces Command at Fort McPherson, Georgia. Prior to this assignment, he served as the 28th Chief of Ordnance and Commandant of the U.S. Army Ordnance School at Aberdeen Proving Grounds, Maryland.

Major General John Francis Wharton is a retired United States Army officer and career logistics officer who last served as the commanding general of the U.S. Army Research, Development and Engineering Command at Aberdeen Proving Ground, Maryland. Before that, Wharton served as the commanding general of U.S. Army Sustainment Command and Rock Island Arsenal, and as the senior commander for U.S. Army Garrison, Rock Island, Illinois.