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Grey's Anatomy season 22

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Grey's Anatomy
Season 22
Greys Anatomy season 22 promotional poster.jpg
Promotional poster
ShowrunnerMeg Marinis
Starring
No. of episodes16
Release
Original network ABC
Original releaseOctober 9, 2025 (2025-10-09) 
present
Season chronology
 Previous
Season 21
List of episodes

The twenty-second season of the American medical drama television series Grey's Anatomy was announced on April 3, 2025, and premiered in the United States on the American Broadcasting Company (ABC) on October 9, 2025. [1] [2]

Contents

This is the first season not to feature Jake Borelli and Midori Francis as series regulars since the sixteenth and nineteenth seasons, respectively. [3]

On March 25, 2026, it was announced that series regulars Kevin McKidd (Dr. Owen Hunt) and Kim Raver (Dr. Teddy Altman) will depart the series after the season finale. [4]

Episodes

No.
overall
No. in
season
Title [5] Directed byWritten by [6] Original release date [5] U.S. viewers
(millions)
4491"Only the Strong Survive" Debbie Allen Meg MarinisOctober 9, 2025 (2025-10-09)2.61 [7]
After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own. Confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation.
4502"We Built This City" Kevin McKidd Zoanne Clack October 16, 2025 (2025-10-16)2.22 [8]
The team at Grey Sloan navigates a chaotic first day of surgical rotations amid hospital renovations. Ben accepts the position of chief resident and Meredith and Maggie spend time with Amelia.
4513"Between Two Lungs"Debbie AllenSandra HamadaOctober 23, 2025 (2025-10-23)2.16 [9]
A high-risk lung transplant pushes the surgical team to their limits. Meanwhile, Bailey juggles a trauma patient whose treatment hangs in the balance.
4524"Goodbye Horses" Sammi Cannold Jase Miles-PerezOctober 30, 2025 (2025-10-30)2.13 [10]
The interns juggle a bizarre trauma, while a complex breast reconstruction forces Meredith into a tense partnership.
4535"Sometimes I Feel Like a Motherless Child" Bille Woodruff Jess RighthandNovember 6, 2025 (2025-11-06)2.04 [11]
Jo navigates a challenging case with a pregnant mother, while Blue and Jules care for a diabetic patient. Meanwhile, Simone treats a patient with a surprising revelation.
4546"When I Crash" Phylicia Rashad Michelle LirtzmanNovember 13, 2025 (2025-11-13)1.84 [12]
Grey Sloan takes in patients following a catastrophic bus accident. Teddy and Owen have an awkward encounter, and Richard tests Bailey’s patience.
4557"Skyfall" Allison Liddi-Brown Carol BrownJanuary 8, 2026 (2026-01-08)2.04 [13]
Winston performs an emergency C-section on Jo, delivering twin girls, but Jo’s cardiomyopathy worsens and she is left in a coma after a cardiac pump is placed. Both newborns are admitted to the NICU; one stabilizes quickly, while the other is treated for a heart murmur. As Link struggles to cope, colleagues rally to support the family. Jo later regains consciousness, and her baby’s condition improves. Elsewhere, Jules Millin confronts her feelings for Winston after treating a critically injured patient but finds him flirting in the bar, while Simone Griffith abandons their celibacy pact and reconnects with Wes. Bailey urges Richard Webber to follow up on his cancer diagnosis, and Lucas Adams grows closer to a terminally ill patient.
4568"Heavy On Me"Lisa LeoneTameson DuffyJanuary 15, 2026 (2026-01-15)2.23 [14]
Richard Webber decides to proceed with surgical treatment for his prostate cancer after consulting an outside specialist and reconsidering a watch-and-wait approach. Bailey and Owen lead a multidisciplinary team in the successful removal of a 35-pound abdominal tumor using ECMO support, and Owen proposes expanded trauma training opportunities for residents. Jules Millin reflects on her social detachment and begins engaging more openly with others. Jo Wilson continues recovering from postpartum complications while spending time with her newborn twins in the NICU and identifies eclampsia in another patient, directing emergency treatment that stabilizes the patient.
4579"Fortunate Son" Kim Raver Julie WongJanuary 22, 2026 (2026-01-22)2.45 [15]
Richard continues to navigate his health. Meanwhile, Meredith and Nick are visited by Nick’s estranged sister from Boston.
45810"Strip That Down"Kevin McKiddMin-Woo ParkJanuary 29, 2026 (2026-01-29)2.44 [16]
Addison Montgomery returns to Grey Sloan, seeking assistance with a patient with a neurological condition. Bailey joins Owen and Blue on a paramedic ride-along.
45911"(If You Want It) Do It Yourself" Linda Klein Scott D. BrownFebruary 26, 2026 (2026-02-26)2.25 [17]
Teddy and Winston clash over a case, while Owen and Jules treat a urologist. Lucas struggles with prioritizing patients.
This episode is dedicated to the memory of Eric Dane, (who portrayed Dr. Mark Sloan), who died of amyotrophic lateral sclerosis (ALS) on February 19, 2026. [18]
46012"Get Lucky" Chandra Wilson Jess RighthandMarch 5, 2026 (2026-03-05)2.15 [19]
Tensions rise as Teddy and Winston take on a complex procedure, while Kavita and Ben try and impress the new plastics attending. Jo and Link leave the babies with a nanny for the first time.
46113"Love the Way You Lie"Allison Liddi-BrownSophia ArnaoMarch 12, 2026 (2026-03-12)2.22 [20]
Richard tackles a shocking case on his first day back, while Kavita and Jules prepare for a high-stakes presentation. Bailey must have a difficult conversation with a beloved patient, and Jo works to baby-proof the loft.
46214"Wrecking Ball"Kevin McKiddMichelle LirtzmanMarch 19, 2026 (2026-03-19)2.37 [21]
A couple lands in the hospital with life-altering injuries after a wrecking ball destroys their home. Lucas and Simone struggle to support a young, terminally ill patient, and Richard hosts a prostate screening event.
46315"Take Me to the River"Bille WoodruffJase Miles-PerezMarch 26, 2026 (2026-03-26)2.65 [22]
Bailey and Blue are forced to confront the emotional costs of experimental care. Meanwhile, Owen, Teddy, Simone and Dani help out at a busy rural hospital, and Richard attempts to spread information about early prostate screenings to the community.
46416"Feel It Still" Jake Borelli Sandra HamadaApril 2, 2026 (2026-04-02)2.38 [23]
Jo returns for her first full day back from leave, and Owen struggles to keep it together when someone close to him is admitted to Grey Sloan. Meanwhile, Bailey navigates hospital leadership.
46517"Through the Fire"Debbie AllenJulie WongApril 30, 2026 (2026-04-30)TBD
46618"Bridge over Troubled Water"Kevin McKiddMeg MarinisMay 7, 2026 (2026-05-07)TBD

Cast and characters

Main

Recurring

Notable guests

Production

Development

On April 3, 2025, ABC renewed the series for a twenty-second season with Meg Marinis' third year as showrunner. [1] The season consists of 18 episodes, consistent with the episode order of Season 21. [28] It surpassed the 450 episode mark during episode 2, extending its record as the longest-running American primetime medical drama. [29] Filming began on August 1. [30] Season 22 premiered in the United States on October 9, 2025. [31]

Casting

Ellen Pompeo will continue to narrate the series and receive star billing, appearing in seven episodes, as she did in Season 21. [32] Chandra Wilson and James Pickens Jr. remain the only original cast members confirmed to appear in all 18 episodes. [33] On October 9, 2025, Trevor Jackson, who guest starred as Dr. Wes Bryant in the last two episodes of Season 21, was promoted to a series regular. [24]

Continuing from last season, the minimum episode guarantee for most series regulars was reduced to 14 out of 18 episodes. However, longtime cast member Caterina Scorsone's role was further scaled back, resulting in a total of 11 appearances for the season. Following her character's sabbatical in episode two, Scorsone was absent for seven episodes, returning for episode 10 in January 2026. [34]

In November 2025, James Pickens Jr. opened up about his prostate cancer diagnosis, which now mirrors the storyline of his character Dr. Richard Webber, who revealed he has cancer in the mid-season finale. Subsequently, he announced being cancer-free. [35] [36]

In December 2025, it was revealed that Kate Walsh will reprise her role as Dr. Addison Montgomery in episode 10, titled "Strip That Down", airing January 29, 2026. [27]

In January 2026, actress Jamie-Lynn Sigler would guest star as Dr. Laura Kaplan, a doctor suffering from multiple sclerosis (MS), in episode which "Heavy on Me," which aired on January 15, 2026. [37] [38] The guest appearance was a nod to Sigler's real life MS condition and was also deemed a way of showing her real life condition openly to a television audience. [37] [39]

On March 25, 2026, it was announced that series regulars Kevin McKidd (Dr. Owen Hunt) and Kim Raver (Dr. Teddy Altman) will depart the series after the season finale. [40]

Future

In February 2026, Grey's Anatomy was reported to likely receive a 23rd season renewal from ABC. The potential renewal was said to involve additional budget reductions, which could affect the episode order and cast. In recent seasons, veteran cast members had already seen their episode guarantees reduced as part of cost-cutting measures, and further cast departures were described as possible. [41] On March 30, 2026, ABC officially renewed the series for a twenty-third season with Meg Marinis' fourth year as showrunner. [42]

Reception

Ratings

Viewership and ratings per episode of Grey's Anatomy season 22
No.TitleAir dateTimeslot (ET) Rating/share
(18–49)
Viewers
(millions)
DVR
(18–49)
DVR viewers
(millions)
Total
(18–49)
Total viewers
(millions)
Ref.
1"Only the Strong Survive"October 9, 2025Thursday 10:00 p.m.0.3/32.610.21.740.45.20 [7]
2"We Built This City"October 16, 20250.2/22.200.31.680.43.90 [8]
3"Between Two Lungs"October 23, 20250.2/32.160.21.560.53.73 [9]
4"Goodbye Horses"October 30, 20250.2/32.130.21.240.43.37 [10]
5"Sometimes I Feel Like a Motherless Child"November 6, 20250.2/22.040.21.030.33.07 [11]
6"When I Crash"November 13, 20250.1/21.84N/aN/aN/aN/a [12]
7"Skyfall"January 8, 20260.2/22.04N/aN/aN/aN/a [13]
8"Heavy On Me"January 15, 20260.2/32.23N/aN/aN/aN/a [14]
9"Fortunate Son"January 22, 20260.2/32.45N/aN/aN/aN/a [15]
10"Strip That Down"January 29, 20260.2/32.44N/aN/aN/aN/a [16]
11"(If You Want It) Do It Yourself"February 26, 20260.2/32.25N/aN/aN/aN/a [17]
12"Get Lucky"March 5, 20260.2/32.15N/aN/aN/aN/a [19]
13"Love the Way You Lie"March 12, 20260.2/32.22N/aN/aN/aN/a [20]
14"Wrecking Ball"March 19, 20260.2/32.37N/aN/aN/aN/a [21]
15"Take Me to the River"March 26, 20260.2/32.65N/aN/aN/aN/a [22]
16"Feel It Still"April 2, 20260,19/32.38N/aN/aN/aN/a [23]

References

  1. 1 2 Otterson, Joe (April 3, 2025). "'9-1-1,' 'Grey's Anatomy,' 'The Rookie,' 'Shifting Gears,' 'Will Trent' Renewed at ABC". Variety . Retrieved July 15, 2025.
  2. White, Peter (July 29, 2025). "ABC Moves Up 'Grey's Anatomy', '9-1-1' & '9-1-1: Nashville' Premiere Dates". Deadline Hollywood . Retrieved July 29, 2025.
  3. Venable, Malcom (December 4, 2024). "'Grey's Anatomy' Showrunner Meg Marinis on That Shocking Mid-Season Finale, Two Big Departures, and What's Coming Next". Shondaland . Retrieved July 22, 2025.
  4. Andreeva, Nellie (March 25, 2026). "'Grey's Anatomy' Shocker: Kim Raver & Kevin McKidd Leaving; Creator Shonda Rhimes Teases "Happy Ending" For Teddy & Owen". Deadline Hollywood . Retrieved March 25, 2026.
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  6. "Grey's Anatomy". Writers Guild of America West . Retrieved February 5, 2026.
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  8. 1 2 Pucci, Douglas (October 17, 2025). "Thursday Ratings: CBS Leads Broadcast Networks Among Total Viewers, Year-Over-Year Erosion in Key Demos for Linear Overall". Programming Insider. Retrieved October 20, 2025.
  9. 1 2 Pucci, Douglas (October 27, 2025). "Thursday Ratings: Ghosts on CBS Earns Top 18-49 and 25-54 Demos Among Prime Time Broadcast Network Telecasts". Programming Insider. Retrieved October 27, 2025.
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  12. 1 2 Pucci, Douglas (November 17, 2025). "Thursday Ratings: 26th Annual Latin Grammy Awards Televised on Univision". Programming Insider. Retrieved November 17, 2025.
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  22. 1 2 Berman, Marc (March 23, 2026). "March Madness Leads CBS to Solid Thursday Victory". Programming Insider.{{cite web}}: CS1 maint: url-status (link)
  23. 1 2 Berman, Marc (April 6, 2026). "'Georgie & Mandy's First Marriage' on CBS Tops Thursday". Programming Insider.{{cite web}}: CS1 maint: url-status (link)
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