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Diphenhydramine/lorazepam/zolpidem

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Diphenhydramine/lorazepam/zolpidem
Combination of
Diphenhydramine Antihistamine (histamine H1 receptor antagonist) and anticholinergic (muscarinic acetylcholine receptor antagonist)
Lorazepam Benzodiazepine (GABAA receptor positive allosteric modulator)
Zolpidem Z drug/nonbenzodiazepine (GABAA receptor positive allosteric modulator)
Clinical data
Other namesSM-1; SM1
Routes of
administration 		Oral [1]

Diphenhydramine/lorazepam/zolpidem (developmental code name SM-1) is a combination of the antihistamine and anticholinergic diphenhydramine, the benzodiazepine lorazepam, and the Z drug/nonbenzodiazepine zolpidem which is or was under development for the treatment of insomnia. [1] [2] [3] [4] [5] It is taken orally. [1] Both lorazepam and zolpidem are GABAA receptor positive allosteric modulators. [6] The combination was originated by Sequential Medicine and is under development by Eusol Biotech. [1] As of October 2024, it is in phase 3 clinical trials for insomnia. [1] However, another source lists the drug as having been discontinued. [2]

See also

References

  1. 1 2 3 4 5 "Diphenhydramine/lorazepam/zolpidem". AdisInsight. 22 October 2024. Retrieved 15 January 2026.
  2. 1 2 "Delving into the Latest Updates on Diphenhydramine/Lorazepam/Zolpidem with Synapse". Synapse. 8 May 2025. Retrieved 15 January 2026.
  3. ↑ Dahl T, Chen LB, Scheinin M, Suopanki-Lalowski J, Valge M, Puhakka A, et al. (November 2019). "Pharmacodynamic and pharmacokinetic profile of SM-1, a triple-drug combination to increase total sleep time". Human Psychopharmacology. 34 (6) e2716. doi:10.1002/hup.2716. PMID   31794072.
  4. ↑ Dahl T, Chen LB, Zammit G, Ahmad M, Roth T (November 2019). "Efficacy of SM-1 in a transient insomnia model". Human Psychopharmacology. 34 (6) e2713. doi:10.1002/hup.2713. PMID   31837050.
  5. ↑ Dahl T, Zammit G, Ahmad M, Rosenberg R, Chen LB, Roth T (January 2022). "Efficacy of the triple-combination SM-1 in a 5-h phase advance transient insomnia model". Sleep and Biological Rhythms. 20 (1): 47–52. doi:10.1007/s41105-021-00338-5. PMC   10897638 . PMID   38469063.
  6. ↑ Krystal AD (December 2023). "Insomnia medications: History, characteristics, and guidelines for optimal use in clinical practice". Journal of Sleep Research. 32 (6) e14084. doi:10.1111/jsr.14084. PMID   37940337.
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