chlordecone reductase
Identifiers
EC no.	1.1.1.225
CAS no.	102484-73-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a chlordecone reductase (EC 1.1.1.225) is an enzyme that catalyzes the chemical reaction

chlordecone alcohol + NADP⁺${\displaystyle \rightleftharpoons }$ chlordecone + NADPH + H⁺

Thus, the two substrates of this enzyme are chlordecone alcohol and NADP⁺, whereas its 3 products are chlordecone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is chlordecone-alcohol:NADP⁺ 2-oxidoreductase. This enzyme is also called CDR.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2FVL.

References

• Molowa DT, Shayne AG, Guzelian PS (1986). "Purification and characterization of chlordecone reductase from human liver". J. Biol. Chem. 261 (27): 12624–7. doi: 10.1016/S0021-9258(18)67136-4 . PMID   2427522.