The branched chain amino acid:cation symporter (LIVCS) family (TC# 2.A.26) is a member of the APC superfamily. Characterized members of this family transport all three of the branched chain aliphatic amino acids (leucine (L), isoleucine (I) and valine (V)). These proteins are found in Gram-negative and Gram-positive bacteria and function by a Na⁺ or H⁺ symport mechanism. They possess about 440 amino acyl residues and display 12 putative transmembrane helical spanners. ^[1] As of early 2016, no crystal structures for members of the LIVCS family are available on RCSB.

Contents

• Transport reaction
• Proteins
• References
• Further reading

Transport reaction

The generalized transport reaction is: ^[1]

[L, I or V] (out) + [Na⁺ or H⁺] (out) → [L, I or V] (in) + [Na⁺ or H⁺] (in).

Proteins

As of early 2016, there are 10 known proteins in the LIVCS family. These can be found in the Transporter Classification Database.

References

Further reading

• Braun, PR; Al-Younes, H; Gussmann, J; Klein, J; Schneider, E; Meyer, TF (2008). "Competitive inhibition of amino acid uptake suppresses chlamydial growth: involvement of the chlamydial amino acid transporter BrnQ". J. Bacteriol. 190: 1822–30. doi:10.1128/JB.01240-07. PMC   2258683 . PMID   18024516.
• Böhmer, C; Rauhut, OW; Wörheide, G (2015). "Correlation between Hox code and vertebral morphology in archosaurs". Proc. Biol. Sci. 282. doi:10.1098/rspb.2015.0077. PMC   4590465 . PMID   26085583.
• Trip, H; Mulder, NL; Lolkema, JS (2013). "Cloning, expression, and functional characterization of secondary amino acid transporters of Lactococcus lactis". J. Bacteriol. 195: 340–50. doi:10.1128/JB.01948-12. PMC   3553839 . PMID   23144255.
• Reizer, J; Reizer, A; Saier, MH (June 1994). "A functional superfamily of sodium/solute symporters". Biochim. Biophys. Acta. 1197: 133–66. PMID   8031825.

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